Background: Presently, it is difficult to use BMSCs in bone regeneration because the cells
are severely weakened or even die after transplantation into the body after in vitro culture …

Osteogenic differentiation of human mesenchymal stem cells (hMSCs) into osteoblasts is a
prerequisite for subsequent bone formation. Numerous studies have explored osteogenic …

Osteogenesis of mesenchymal stem cells (MSCs) is highly dependent on oxygen supply.
We have shown that perfluorotributylamine (PFTBA), a synthetic oxygen carrier, enhances …

Objective To investigate the role of bone morphogenetic protein 2 (BMP-2) combined with
hypoxic microenvironment in chondrogenic phenotype differentiation of bone marrow …

Mesenchymal stem cells (MSCs), which can be isolated from bone marrow and other
somatic tissues, are residing in an environment with relative low oxygen tension. The …

Cell-based approaches for musculoskeletal tissue repair are limited by poor cell survival
and engraftment. Short-term hypoxic preconditioning of mesenchymal stem cells (MSCs) …

Objective Heterotopic ossification (HO), also known as ossifying myositis, is a condition that
produces abnormal bone and cartilage tissue in the soft tissues. Hypoxia inducible factor lα …

Introduction The capacity of bone marrow mesenchymal stromal cells (BMSCs) to be
induced into chondrocytes has drawn much attention for cell-based cartilage repair. BMSCs …

This study aimed to examine the proliferative behavior and molecular mechanisms of rat
bone marrow-derived MSCs (rBMSCs) cultured under three different oxygen concentrations …

BACKGROUND: Hypoxia is one of the main driving forces regulating the angiogenesis-
osteogenesis differentiation process. Hypoxia treatment of cells before differentiation is …