An approach is described to the design of β-hairpin peptidomimetic ligands for bovine
immunodeficiency virus (BIV) Tat protein, which inhibit binding to its transactivator response …

The Tat protein of immunodeficiency viruses is the main activator of viral gene expression.
By binding specifically to its cognate site, the transactivator response element (TAR), Tat …

The search for new antiviral drugs that repress HIV viral replication by blocking
transactivation of viral RNA transcription has long been advocated as an approach to novel …

RNA-protein interfaces control key replication events during the HIV-1 life cycle. The viral
trans-activator of transcription (Tat) protein uses an archetypal arginine-rich motif (ARM) to …

The pharmacological disruption of the interaction between the HIV Tat protein and its
cognate transactivation response RNA (TAR) would generate novel anti-viral drugs with a …

The interaction of the HIV-1 transactivator protein Tat with its transactivation response (TAR)
RNA is an essential step in viral replication and therefore an attractive target for developing …

Small peptides with unnatural backbones that can bind with high affinity to any
predetermined RNA structure would provide useful tools in molecular biology and medicine …

An oligopyridylamide‐based foldamer approach has been employed to target HIV TAR RNA‐
TAT assembly as a model system to study RNA‐protein interactions. The oligopyridylamide …

The interaction between the HIV-1 Tat protein and the TAR RNA element in the nascent viral
genomic transcript is required for viral replication. An 11-residue β-peptide (1), an all-β …

Small molecules that bind to RNA potently and specifically are relatively rare. The study of
molecules that bind to the HIV-1 transactivation response (TAR) hairpin, a cis-acting HIV …