Inhibitors of protein− RNA complexation that target the RNA: specific recognition of human immunodeficiency virus type 1 TAR RNA by small organic molecules
HY Mei, M Cui, A Heldsinger, SM Lemrow, JA Loo… - Biochemistry, 1998 - ACS Publications
TAR RNA represents an attractive target for the intervention of human immunodeficiency
virus type 1 (HIV-1) replication by small molecules. We now describe three small molecule …
virus type 1 (HIV-1) replication by small molecules. We now describe three small molecule …
An ultra-high affinity ligand of HIV-1 TAR reveals the RNA structure recognized by P-TEFb
MD Shortridge, PT Wille, AN Jones… - Nucleic acids …, 2019 - academic.oup.com
The HIV-1 trans-activator protein Tat binds the trans-activation response element (TAR) to
facilitate recruitment of the super elongation complex (SEC) to enhance transcription of the …
facilitate recruitment of the super elongation complex (SEC) to enhance transcription of the …
[HTML][HTML] Structure of TAR RNA complexed with a Tat-TAR interaction nanomolar inhibitor that was identified by computational screening
Z Du, KE Lind, TL James - Chemistry & biology, 2002 - cell.com
Abstract HIV-1 TAR RNA functions critically in viral replication by binding the transactivating
regulatory protein Tat. We recently identified several compounds that experimentally inhibit …
regulatory protein Tat. We recently identified several compounds that experimentally inhibit …
Design of a cyclic peptide that targets a viral RNA
ST Runyon, JD Puglisi - Journal of the American Chemical …, 2003 - ACS Publications
The Tat protein controls transcription in lentiviruses such as HIV. A cyclic peptide analog of
the RNA binding domain of the bovine immunodeficiency virus (BIV) Tat protein is shown to …
the RNA binding domain of the bovine immunodeficiency virus (BIV) Tat protein is shown to …
An evolved RNA recognition motif that suppresses HIV-1 Tat/TAR-dependent transcription
DW Crawford, BD Blakeley, PH Chen… - ACS chemical …, 2016 - ACS Publications
Potent and selective recognition and modulation of disease-relevant RNAs remain a
daunting challenge. We previously examined the utility of the U1A N-terminal RNA …
daunting challenge. We previously examined the utility of the U1A N-terminal RNA …
Molecular recognition in the bovine immunodeficiency virus Tat peptide-TAR RNA complex
Background: In lentiviruses such as human immunodeficiency virus (HIV) and bovine
immunodeficiency virus (BIV), the Tat (trunr-activating) protein enhances transcription of the …
immunodeficiency virus (BIV), the Tat (trunr-activating) protein enhances transcription of the …
Targeting RNA with peptidomimetic oligomers in human cells
N Tamilarasu, I Huq, TM Rana - Bioorganic & medicinal chemistry letters, 2001 - Elsevier
Replication of human immunodeficiency virus type 1 (HIV-1) requires specific interactions of
Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base stem-loop …
Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base stem-loop …
Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic “hot spots”
The targeting of RNA for the design of novel anti-viral compounds has until now proceeded
largely without incorporating direct input from structure-based design methodology, partly …
largely without incorporating direct input from structure-based design methodology, partly …
A new class of RNA-binding oligomers: peptoid amide and ester analogues
V Kesavan, N Tamilarasu, H Cao… - Bioconjugate …, 2002 - ACS Publications
Replication of human immunodeficiency virus type 1 (HIV-1) requires specific interactions of
Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base stem-loop …
Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base stem-loop …
A single intermolecular contact mediates intramolecular stabilization of both RNA and protein
V Calabro, MD Daugherty… - Proceedings of the …, 2005 - National Acad Sciences
An arginine-rich peptide from the Jembrana disease virus (JDV) Tat protein is a structural
“chameleon” that binds bovine immunodeficiency virus (BIV) or HIV TAR RNAs in two …
“chameleon” that binds bovine immunodeficiency virus (BIV) or HIV TAR RNAs in two …