Natural and lab-evolved proteins often recognize their RNA partners with exquisite affinity.
Structural analysis of such complexes can offer valuable insight into sequence-selective …

Competitive binding of peptides containing basic amino acids to disrupt or prevent the Tat–
TAR interaction could result in diminished transcription as well as translation and hence …

The recognition that RNA is more than just an intermediate in the information transfer from
genetic code to fully functional protein has placed it at the forefront of chemical research …

Basic peptides from the carboxy terminus of the HIV-1 Tat protein bind to the apical stem−
loop region of TAR RNA with high affinity and moderate specificity. The conformations of the …

Aminoglycoside antibiotics were found for the first time to inhibit an HIV-1 Tat-derived
peptide binding to TAR RNA. The IC50 values of neomycin, streptomycin, and gentamicin …

Four new isoquinoline derivatives bearing guanidinium group or amino group-terminated
side chain were synthesized to target the HIV-1 TAR element. Their abilities to bind TAR …

Abstract The HIV-1 TAR RNA represents a well-known paradigm to study the role of
dynamics and conformational change in RNA function. This regulatory RNA changes …

Efficient replication and gene expression of human immunodeficiency virus-1 (HIV-1)
involves specific interaction of the viral protein Tat, with its trans-activation responsive …

Trans-activation of HIV-1 by the Tat protein is mediated through a cis-acting element (TAR)
in the viral RNA. In order to obtain further insight into the molecular interactions for trans …

Small unnatural peptides that target specific RNA structures have the potential to control
biological processes. RNA− protein interactions are important in many cellular functions …