Integrative proteomics and metabolomics approach to elucidate metabolic dysfunction induced by silica nanoparticles in hepatocytes

Y Zhu, Y Zhang, Y Li, C Guo, Z Fan, Y Li, M Yang… - Journal of Hazardous …, 2022 - Elsevier
Silica nanoparticles (SiNPs) are derived from manufactured materials and the natural
environment, and they cause detrimental effects on human health via various exposure …

[HTML][HTML] Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress

A Abulikemu, X Zhao, H Xu, Y Li, R Ma, Q Yao, J Wang… - Redox Biology, 2023 - Elsevier
The metabolic associated fatty liver disease (MAFLD) is a public health challenge, leading to
a global increase in chronic liver disease. The respiratory exposure of silica nanoparticles …

Adverse effects and underlying mechanism of amorphous silica nanoparticles in liver

Q Liang, M Sun, Y Ma, F Wang, Z Sun, J Duan - Chemosphere, 2023 - Elsevier
Amorphous silica nanoparticles (SiNPs) have been widely used and mass-producted due to
its unique properties. With the life cycle of SiNPs-based products, SiNPs are further released …

Oxidative stress-and mitochondrial dysfunction-mediated cytotoxicity by silica nanoparticle in lung epithelial cells from metabolomic perspective

X Zhao, A Abulikemu, S Lv, Y Qi, J Duan, J Zhang… - Chemosphere, 2021 - Elsevier
Quantities of researches have demonstrated silica nanoparticles (SiNPs) exposure
inevitably induced damage to respiratory system, nonetheless, knowledge of its toxicological …

Global metabolomics approach in in vitro and in vivo models reveals hepatic glutathione depletion induced by amorphous silica nanoparticles

N Chatterjee, J Jeong, D Yoon, S Kim, J Choi - Chemico-Biological …, 2018 - Elsevier
The present study aimed to investigate the mechanisms involved in amorphous silica
nanoparticles (aSiNPs)-mediated hepatotoxicity through the evaluation of changes in global …

[HTML][HTML] Metabolomic characteristics of hepatotoxicity in rats induced by silica nanoparticles

M Sun, J Zhang, S Liang, Z Du, J Liu, Z Sun… - … and Environmental Safety, 2021 - Elsevier
Silica nanoparticles (SiNPs) have become one of the most widely studied nanoparticles in
nanotechnology for environmental health and safety. Although many studies have devoted …

Disturbed mitochondrial quality control involved in hepatocytotoxicity induced by silica nanoparticles

Y Qi, R Ma, X Li, S Lv, X Liu, A Abulikemu, X Zhao, Y Li… - Nanoscale, 2020 - pubs.rsc.org
The extensive application of silica nanoparticles (SiNPs) brings about inevitable
occupational, environmental, and even iatrogenic exposure for human beings. The liver …

Risk assessment of silica nanoparticles on liver injury in metabolic syndrome mice induced by fructose

J Li, X He, Y Yang, M Li, C Xu, R Yu - Science of the total environment, 2018 - Elsevier
This study aims to assess the effects and the mechanisms of silica nanoparticles (SiNPs) on
hepatotoxicity in both normal and metabolic syndrome mouse models induced by fructose …

Global proteomics to study silica nanoparticle-induced cytotoxicity and its mechanisms in HepG2 cells

SY Lee, IY Kim, MB Heo, JH Moon, JG Son, TG Lee - Biomolecules, 2021 - mdpi.com
Silica nanoparticles (SiO2 NPs) are commonly used in medical and pharmaceutical fields.
Research into the cytotoxicity and overall proteomic changes occurring during initial …

Silica nanoparticles induce hepatotoxicity by triggering oxidative damage, apoptosis, and Bax-Bcl2 signaling pathway

B Aouey, K Boukholda, B Gargouri, HS Bhatia… - Biological trace element …, 2022 - Springer
The increase in the usage of silica nanoparticles (SiNPs) in the industrial and medical fields
has raised concerns about their possible adverse effects on human health. The present …