Integrative proteomics and metabolomics approach to elucidate metabolic dysfunction induced by silica nanoparticles in hepatocytes
Y Zhu, Y Zhang, Y Li, C Guo, Z Fan, Y Li, M Yang… - Journal of Hazardous …, 2022 - Elsevier
Silica nanoparticles (SiNPs) are derived from manufactured materials and the natural
environment, and they cause detrimental effects on human health via various exposure …
environment, and they cause detrimental effects on human health via various exposure …
[HTML][HTML] Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress
A Abulikemu, X Zhao, H Xu, Y Li, R Ma, Q Yao, J Wang… - Redox Biology, 2023 - Elsevier
The metabolic associated fatty liver disease (MAFLD) is a public health challenge, leading to
a global increase in chronic liver disease. The respiratory exposure of silica nanoparticles …
a global increase in chronic liver disease. The respiratory exposure of silica nanoparticles …
Adverse effects and underlying mechanism of amorphous silica nanoparticles in liver
Q Liang, M Sun, Y Ma, F Wang, Z Sun, J Duan - Chemosphere, 2023 - Elsevier
Amorphous silica nanoparticles (SiNPs) have been widely used and mass-producted due to
its unique properties. With the life cycle of SiNPs-based products, SiNPs are further released …
its unique properties. With the life cycle of SiNPs-based products, SiNPs are further released …
Oxidative stress-and mitochondrial dysfunction-mediated cytotoxicity by silica nanoparticle in lung epithelial cells from metabolomic perspective
X Zhao, A Abulikemu, S Lv, Y Qi, J Duan, J Zhang… - Chemosphere, 2021 - Elsevier
Quantities of researches have demonstrated silica nanoparticles (SiNPs) exposure
inevitably induced damage to respiratory system, nonetheless, knowledge of its toxicological …
inevitably induced damage to respiratory system, nonetheless, knowledge of its toxicological …
Global metabolomics approach in in vitro and in vivo models reveals hepatic glutathione depletion induced by amorphous silica nanoparticles
The present study aimed to investigate the mechanisms involved in amorphous silica
nanoparticles (aSiNPs)-mediated hepatotoxicity through the evaluation of changes in global …
nanoparticles (aSiNPs)-mediated hepatotoxicity through the evaluation of changes in global …
[HTML][HTML] Metabolomic characteristics of hepatotoxicity in rats induced by silica nanoparticles
M Sun, J Zhang, S Liang, Z Du, J Liu, Z Sun… - … and Environmental Safety, 2021 - Elsevier
Silica nanoparticles (SiNPs) have become one of the most widely studied nanoparticles in
nanotechnology for environmental health and safety. Although many studies have devoted …
nanotechnology for environmental health and safety. Although many studies have devoted …
Disturbed mitochondrial quality control involved in hepatocytotoxicity induced by silica nanoparticles
Y Qi, R Ma, X Li, S Lv, X Liu, A Abulikemu, X Zhao, Y Li… - Nanoscale, 2020 - pubs.rsc.org
The extensive application of silica nanoparticles (SiNPs) brings about inevitable
occupational, environmental, and even iatrogenic exposure for human beings. The liver …
occupational, environmental, and even iatrogenic exposure for human beings. The liver …
Risk assessment of silica nanoparticles on liver injury in metabolic syndrome mice induced by fructose
J Li, X He, Y Yang, M Li, C Xu, R Yu - Science of the total environment, 2018 - Elsevier
This study aims to assess the effects and the mechanisms of silica nanoparticles (SiNPs) on
hepatotoxicity in both normal and metabolic syndrome mouse models induced by fructose …
hepatotoxicity in both normal and metabolic syndrome mouse models induced by fructose …
Global proteomics to study silica nanoparticle-induced cytotoxicity and its mechanisms in HepG2 cells
Silica nanoparticles (SiO2 NPs) are commonly used in medical and pharmaceutical fields.
Research into the cytotoxicity and overall proteomic changes occurring during initial …
Research into the cytotoxicity and overall proteomic changes occurring during initial …
Silica nanoparticles induce hepatotoxicity by triggering oxidative damage, apoptosis, and Bax-Bcl2 signaling pathway
B Aouey, K Boukholda, B Gargouri, HS Bhatia… - Biological trace element …, 2022 - Springer
The increase in the usage of silica nanoparticles (SiNPs) in the industrial and medical fields
has raised concerns about their possible adverse effects on human health. The present …
has raised concerns about their possible adverse effects on human health. The present …