Background Cerebrovascular disease (CVD) and amyloid-β (Aβ) often coexist, but their
influence on neurodegeneration and cognition in predementia stages remains unclear. We …

Introduction Cerebrovascular disease (CVD) is not currently considered a core pathological
feature of Alzheimer's disease (AD), but mounting evidence suggests that concurrent CVD …

Background Alzheimer's disease (AD) and vascular contributions to cognitive impairment
and dementia (VCID) pathologies coexist in patients with cognitive impairment. Abnormal …

Objective To determine whether vascular risk and Alzheimer disease (AD) biomarkers have
independent or synergistic effects on cognitive decline and whether vascular risk is …

Objective To determine whether vascular and neurodegenerative factors influence cognition
before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and …

Background: As Alzheimer's disease (AD) and cerebral small vessel disease (CSVD)
commonly coexist, the interaction between two has been of the considerable interest …

Objective Elevated vascular risk and beta‐amyloid (Aβ) burden have been synergistically
associated with cognitive decline in preclinical Alzheimer's disease (AD), although the …

Background: The contribution of vascular pathology to the rate of progression from mild
cognitive impairment (MCI) to Alzheimer's disease (AD) remains unclear. Objective: To …

Background The underlying cause of cognitive decline in individuals who are positive for
biomarkers of neurodegeneration (N) but negative for biomarkers of amyloid‐beta (A) …

Objective Midlife vascular risk factors (MVRFs) are associated with incident dementia, as are
amyloid β (Aβ) deposition and neurodegeneration. Whether vascular and Alzheimer disease …