[HTML][HTML] Role of receptors in relation to plaques and tangles in Alzheimer's disease pathology

K Sharma, S Pradhan, LK Duffy, S Yeasmin… - International Journal of …, 2021 - mdpi.com
Despite the identification of Aβ plaques and NFTs as biomarkers for Alzheimer's disease
(AD) pathology, therapeutic interventions remain elusive, with neither an absolute …

A Recent Update on Pathophysiology and Therapeutic Interventions of Alzheimer's Disease

M Kashif, P Sivaprakasam, P Vijendra… - Current …, 2023 - ingentaconnect.com
Aim: Alzheimer's disease (AD) has been identified as a progressive brain disorder
associated with memory dysfunction and the accumulation of β-amyloid plaques and …

[HTML][HTML] Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

K Rajasekhar, T Govindaraju - RSC advances, 2018 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent, progressive and multifaceted
neurodegenerative disorder associated with cognition, memory and behavioural …

Beyond the classical amyloid hypothesis in Alzheimer's disease: Molecular insights into current concepts of pathogenesis, therapeutic targets, and study models

A Theerasri, S Janpaijit, T Tencomnao… - WIREs Mechanisms …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is one of the progressive neurodegenerative disorders and the
most common cause of dementia in the elderly worldwide causing difficulties in the daily life …

Therapeutic advancement in Alzheimer disease: new hopes on the horizon?

A Singh, A Hasan, S Tiwari… - CNS & neurological …, 2018 - ingentaconnect.com
Background & Objective: Over the last two decades, Alzheimer disease (AD) associated
research has accomplished an overwhelming momentum, as it is one of the major current …

[HTML][HTML] Therapeutic targeting strategies for early-to late-staged Alzheimer's disease

YJ Kang, YN Diep, M Tran, H Cho - International Journal of Molecular …, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia, typically showing
progressive neurodegeneration in aging brains. The key signatures of the AD progression …

Molecular mechanisms of emerging therapeutic targets in Alzheimer's disease: a systematic review

T Premkumar, S Sajitha Lulu - Neurochemical Journal, 2022 - Springer
Alzheimer's disease (AD) is a severe cognitive impairment considered to be the leading
cause of dementia worldwide. The pathophysiology includes extracellular accumulation of …

Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology

J Guo, J Cheng, BJ North, W Wei - … et Biophysica Acta (BBA)-Reviews on …, 2017 - Elsevier
Alzheimer's disease (AD) is an aging-related neurodegenerative disease and accounts for
majority of human dementia. The hyper-phosphorylated tau-mediated intracellular …

Therapeutic perspectives of drugs targeting toll-like receptors based on immune physiopathology theory of Alzheimer's disease

AR Schneider, Y Sari - … (Formerly Current Drug Targets-CNS & …, 2014 - ingentaconnect.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with the development
of dementia. It has been established that the pathological hallmarks of neurofibrillary tau …

Multifaceted Alzheimer's disease: Building a roadmap for advancement of novel therapies

D Kaur, T Behl, A Sehgal, S Singh, N Sharma… - Neurochemical …, 2021 - Springer
Alzheimer's disease (AD) is one of the most prevailing neurodegenerative disorders of
elderly humans associated with cognitive damage. Biochemical, epigenetic, and …