The transition metals iron and copper are required by virtually all organisms but are toxic in
excess. Acquisition of both metals, as well as resistance to copper excess have previously …

Copper is an essential micronutrient for the opportunistic human pathogen, Aspergillus
fumigatus. Maintaining copper homeostasis is critical for survival and pathogenesis. Copper …

Highlights•Aspergillus fumigatus requires metal ion uptake in the host environment.•Metal-
homeostatic circuits are complex and multifactorial.•Imbalances in metal homeostasis affect …

Copper is a metal ion that is required as a micronutrient for growth and proliferation.
However, copper accumulation generates toxicity by multiple mechanisms, potentially …

The Fenton-chemistry-generating properties of copper ions are considered a potent
phagolysosome defense against pathogenic microbes, yet our understanding of underlying …

Aspergillus fumigatus can cause severe invasive aspergillosis in immunocompromised
individuals. Copper, an essential but potentially toxic trace element for A. fumigatus, plays a …

The ubiquitous fungus Aspergillus flavus is notorious for contaminating many important
crops and food-stuffs with the carcinogenic mycotoxin, aflatoxin. This fungus is also the …

Most of the metal transporters in Aspergillus fumigatus are yet uncharacterized. Their role in
fungal metabolism and virulence remains unclear. This paper describes the novel PIB-type …

The physiological background of the unusually high cadmium tolerance (MIC50> 2 mM) of
Aspergillus fumigatus Af293 was investigated. The cadmium tolerance of the tested …

Aspergillus fumigatus is a ubiquitous soil decomposer and an opportunistic pathogen that is
characterized by its large metabolic machinery for acquiring nutrients from media. Lately, an …