Iron plays a central role in manifestation of infections for a variety of pathogens. To ensure
an adequate supply with iron, Aspergillus fumigatus employs extra-and intracellular …

One of the most important features that enables Aspergillus fumigatus to grow within a
susceptible individual and to cause disease is its ability to obtain Zn2+ ions from the …

Iron is an essential nutrient and enzyme co-factor required for a wide range of cellular
processes, especially for the function of mitochondria. For the opportunistic fungal pathogen …

The ability to acquire iron in vivo is essential for most microbial pathogens. Here we show
that Aspergillus fumigatus does not have specific mechanisms for the utilization of host iron …

Efficient adaptation to iron starvation is an essential virulence determinant of the most
common human mold pathogen, Aspergillus fumigatus. Here, we demonstrate that the …

Metals such as Fe, Cu, Zn, and Mn are essential trace nutrients for all kingdoms of life,
including microbial pathogens and their hosts. During infection, the mammalian host …

Copper (Cu) ions serve as catalytic cofactors to drive key biochemical processes, and yet Cu
levels that exceed cellular homeostatic control capacity are toxic. The underlying …

All organisms must secure essential trace elements (eg, Cu) for survival and reproduction.
However, excess trace element accumulation in cells is highly toxic. The maintenance of …

All living organisms, from bacteria to humans, require copper. 1 Copper serves as an
electron transfer intermediate for many enzymes associated with indispensable metabolic …

Recent years have witnessed an explosion in the breadth of investigations on transition
metal homeostasis and the subsequent depth of our understanding of metals in biology …