Optimal dosing of β-lactam antibiotics in critically ill patients is a challenge given the
unpredictable pharmacokinetic profile of this patient population. Several studies have shown …

Pharmacokinetic changes are often seen in patients with severe infections. Administration
by continuous infusion has been suggested to optimize antibiotic exposure and …

Piperacillin plasma concentrations are known to vary between critically ill patients. However,
there are no comprehensive data on the variability of antibiotic concentrations within the …

The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients
with microbiologically documented infections is currently unknown. We conducted a …

The objectives of this study were (i) to compare the plasma concentration–time profiles for
first-dose and steady-state piperacillin administered by intermittent or continuous dosing to …

Purpose Standard dosing and intermittent bolus application (IB) are important risk factors for
pharmacokinetic (PK) target non-attainment during empirical treatment with β-lactams in …

Therapeutic drug monitoring (TDM) is increasingly relevant for an individualized antibiotic
therapy and subsequently a necessary tool to reduce multidrug-resistant pathogens …

Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host
response to infection with a hospital mortality in excess of 40%. Along with insufficient and …

In the present study 24 hospitalized patients requiring empirical antibiotic treatment were
randomly assigned to receive the β-lactam antibiotic/β-lactamase inhibitor combination …

Objective: To perform a qualitative systematic review of the evidence comparing traditional
strategies against prolonged intermittent or continuous infusion strategies for piperacillin …