Introduction: Rheumatoid arthritis (RA) is an autoimmune disease affecting multiple joints in
the body, characterized by chronic inflammation and destruction of cartilaginous structures …

Introduction Fibroblast-like synoviocytes (FLS) play a central role in defining the stromal
environment in inflammatory joint diseases. Despite a growing use of FLS isolated from …

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease affecting synovial joints
and leading to cartilage damage and bone loss. This destruction is promoted by activated …

Background The synovial membrane is a distinctly organised tissue structure. During the
course of rheumatoid arthritis (RA), the synovium becomes hyperplastic and demonstrates …

Conclusion: FLS cells are the main components of maintaining the health and nutrition of
joints. These cells produce various cytokines, chemokines, angiogenic factors, as well as …

Rheumatoid arthritis is an inflammatory disease in which synovial fibroblasts maintain the
persistence of inflammation within the joint, dependent on a unique pathological phenotype …

Purpose: Currently, fibroblast-like synoviocytes (FLS) have been recognized to play a pivotal
role in the pathogenesis and progression of rheumatoid and osteoarthritic joint diseases. In …

Rheumatoid arthritis (RA) is a chronic autoimmune disease that endangers the health of
approximately 1% of the global population. Current RA medications on the market mainly …

Background Fibroblast-like synoviocytes (FLS) are essential cellular components in
inflammatory joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA) …

Despite advances in the treatment of rheumatoid arthritis (RA), currently approved
medications can have significant side effects due to their direct immunosuppressive …