Neuronal regeneration in the central nervous system (CNS) is an important field of research
with relevance to all types of neuronal injuries, including neurodegenerative diseases. The …

Several major factors are known to contribute to CNS axon regenerative failure after injury,
including reduced intrinsic growth capacity of developed neurons and extrinsic factors …

Injury or disease to the CNS results in multifaceted cellular and molecular responses. One
such response, the glial scar, is a structural formation of reactive glia around an area of …

Astrocytes react to CNS injury by building a dense wall of filamentous processes around the
lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective …

Injured nerves regenerate their axons in the peripheral (PNS) but not the central nervous
system (CNS). The contrasting capacities have been attributed to the growth permissive …

After traumatic injuries of the central nervous system (CNS), including spinal cord injury
(SCI), astrocytes surrounding the lesion become reactive and typically undergo hypertrophy …

Axonal regeneration and functional recovery are poor after spinal cord injury (SCI), typified
by the formation of an injury scar. While this scar was traditionally believed to be primarily …

Understanding the regulation of axon growth after injury to the adult central nervous system
(CNS) is crucial to improve neural repair. Following acute focal CNS injury, astrocytes are …

Scar formation represents a reaction of nervous tissue to any form of physical injury.
Research over the past decade has demonstrated that the scar composed of glial cells and …

Damage to the adult CNS often leads to persistent deficits due to the inability of mature
axons to regenerate after injury. Mounting evidence suggests that the glial environment of …