Paul Ehrlich coined the term “magic bullet” to describe how a drug kills the parasite inside its
human host without harming the host itself. Ehrlich concluded that the drug must have a …

The singular structure of artemisinin, with its embedded 1, 2, 4-trioxane heterocycle, has
inspired the discovery of numerous semisynthetic artemisinin and structurally diverse …

The mechanism of action of ozonide antimalarials involves activation by intraparasitic iron
and the formation of highly reactive carbon-centered radicals that alkylate malaria parasite …

Currently, nearly two billion people are at risk of contracting malaria and the incidence of this
disease is dramatically increasing because many Plasmodium falciparum strains, the …

Artemisinin is a sesquiterpene lactone with an endoperoxide function essential for its
antimalarial activity against chloroquine-resistant strains of Plasmodium falciparum. The …

Peroxidic antimalarials such as the semisynthetic artemisinins are critically important in the
treatment of drug-resistant malaria. Nevertheless, their peroxide bond-dependent mode of …

The peroxide bond of the artemisinins inspired the development of a class of fully synthetic
1, 2, 4-trioxolane-based antimalarials, collectively known as the ozonides. Similar to the …

The discovery that the sesquiterpene peroxide yingzhaosu A (13) and 1, 2, 4-trioxane
artemisinin (14) are active against chloroquine-resistant strains of Plasmodium falciparum …

Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a
single-dose oral cure in humans. OZ439 has successfully completed Phase I clinical trials …

In the present work we performed a combined experimental and computational study on the
interaction of the natural antimalarial endoperoxide plakortin and its synthetic analogue 4a …