Saikosaponin d (SSd) is a traditional Chinese medicine that has been widely used in
depression treatment. Given the lack of studies demonstrating the underlying mechanism of …

Background Many studies about depression have focused on the dysfunctional synaptic
signaling in the hippocampus that drives the pathophysiology of depression. Radix Bupleuri …

Accumulating studies have shown that a traditional Chinese decoction Chaihu-Shugan-San
produced the antidepressant-like effects in rodents including in perimenopausal. Previous …

Abstract Rationale Saikosaponin D (SSD), a major bioactive component isolated from Radix
Bupleuri, has been reported to exert neuroprotective properties. Objectives The present …

Abstract Background Bupleurum yinchowense Shan et Y. Li is widely used to treat
depressive and anxiety disorders for hundreds of years in China. Total saikosaponins (TSS) …

Saikosaponin-d (SSd) is a triterpene saponin from the roots of Bupleurum chinese. Recent
studies have revealed its antidepressant activity, but its mechanism involved is unclear. This …

Chronic stress can provoke depressive-like behaviors through activation of inflammation
and apoptosis, leading to a reduction of neurons. Antidepressant therapy may contribute to …

Major depressive disorder is one of the most common neuropsychiatric diseases and it is a
global public health problem that leads to disabilities. Currently, there is a growing need to …

Abstract Background Kai Xin San (KXS) was widely applied for the treatment of depression
for thousands of years. However, the underlying antidepressant mechanism of KXS remains …

Abstract Saikosaponin-d (SSd), a triterpenoid saponins compound extracted from Radix
Bupleuri, has been demonstrated to effectively alleviate chronic mild stress-induced …