Abstract Treatment with the iodine-containing antiarrhythmic drug, amiodarone, can cause
pulmonary toxicity. Alveolar macrophages are particularly susceptible to formation of lipid …

The techniques of cryomicrotomy and X-ray microanalysis were used to quantitatively
measure the subcellular distribution of iodine in rat alveolar macrophages following a single …

When administered to humans and animals, the iodine-containing drug amiodarone can
cause pulmonary toxicity. As part of the pulmonary response to amiodarone, the drug and its …

Administration of the antiarrhythmic drug amiodarone to humans or animals may result in
lung damage. Amiodarone is metabolized to desethylamiodarone and other minor …

Treatment of humans with the antiarrhythmic drug amiodarone can cause pulmonary
pathology and toxicity. The disorder is associated with the accumulation of phospholipid …

Amiodarone is an antiarrhythmic drug that concentrates in the lungs and can cause
pulmonary damage in humans. The purpose of the present study was to examine the …

Administration of amiodarone, although often lifesaving, is associated with pulmonary side
effects. Patients with amiodarone pulmonary toxicity can present with either a chronic …

Amiodarone, a new antiarrhythmic agent, is associated with serious lung toxicity. This study
indicates that in vitro amiodarone can directly induce bovine pulmonary artery endothelial …

A rat model of amiodarone-induced pulmonary toxicity is described. The rats were fed, by
gavage, 175 mg/kg/day of amiodarone hydrochloride suspended in methyl cellulose …

Pulmonary function, chest radiographic appearances, and the cellular composition of
bronchoalveolar lavage fluid were assessed in 13 patients who were receiving amiodarone …