New perspectives on chronic obstructive pulmonary disease

BR Celli, D Singh, C Vogelmeier… - International Journal of …, 2022 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality
worldwide; many recent advances have been made in many aspects of the disease. The aim …

[HTML][HTML] Blood eosinophil levels as a biomarker in COPD

G Brusselle, ID Pavord, S Landis, S Pascoe, S Lettis… - Respiratory …, 2018 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder and patients
respond differently to treatment. Blood eosinophils are a potential biomarker to stratify …

Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: the GOLD science committee report 2019

D Singh, A Agusti, A Anzueto, PJ Barnes… - European …, 2019 - Eur Respiratory Soc
Precision medicine is a patient-specific approach that integrates all relevant clinical, genetic
and biological information in order to optimise the therapeutic benefit relative to the …

Blood eosinophil count-guided corticosteroid therapy and as a prognostic biomarker of exacerbations of chronic obstructive pulmonary disease: a systematic review …

T Liu, ZJ Xiang, XM Hou, JJ Chai… - … in Chronic Disease, 2021 - journals.sagepub.com
Background: Chronic obstructive pulmonary disease (COPD) is characterized by persistent
respiratory symptoms and dyspnea, as well as an increase in the number of leukocytes in …

Pharmacological treatment of stable chronic obstructive pulmonary disease

D Singh - Respirology, 2021 - Wiley Online Library
Pharmacological treatment for chronic obstructive pulmonary disease (COPD) aims to
alleviate symptoms and reduce the future risk of events such as exacerbations, disease …

Blood eosinophil count: a biomarker of an important treatable trait in patients with airway disease

ID Pavord, A Agusti - European Respiratory Journal, 2016 - Eur Respiratory Soc
Inhaled corticosteroids (ICS) are widely used to treat patients with chronic obstructive
pulmonary disease (COPD). Their main impact is to reduce the risk of exacerbations; in …

Blood eosinophils as a marker of response to inhaled corticosteroids in COPD

NC Barnes, R Sharma, S Lettis… - European Respiratory …, 2016 - Eur Respiratory Soc
Identification of a biomarker that predicts response to inhaled corticosteroids (ICS) would
help evaluate the risk/benefit profile of ICS in chronic obstructive pulmonary disease (COPD) …

Shall we focus on the eosinophil to guide treatment with systemic corticosteroids during acute exacerbations of COPD?: PRO

J Camp, JL Cane, M Bafadhel - Medical Sciences, 2018 - mdpi.com
In an era of precision medicine, it seems regressive that we do not use stratified approaches
to direct treatment of oral corticosteroids during an exacerbation of chronic obstructive …

Blood eosinophils as a biomarker of future COPD exacerbation risk: pooled data from 11 clinical trials

D Singh, JA Wedzicha, S Siddiqui, A de la Hoz… - Respiratory …, 2020 - Springer
Background Chronic obstructive pulmonary disease (COPD) is characterised by progressive
airflow limitation and chronic inflammation. Predicting exacerbations of COPD, which …

In 'real world'patients with COPD, exacerbation history, and not blood eosinophils, is the most reliable predictor of future exacerbations

H Worth, R Buhl, CP Criée, P Kardos, E Gückel… - Respiratory …, 2023 - Springer
Introduction There is an interest in the role of blood eosinophils for predicting inhaled
corticosteroid (ICS) response in chronic obstructive pulmonary disease (COPD). Most data …