Simple Summary Organ-on-a-chip models, or organ chips, are tiny devices designed to
accurately recreate the natural physiology and mechanical forces that cells experience in …

One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …

The transition to increasingly sophisticated microfluidic systems has led to the emergence of
“organ-on-chip” technology that can faithfully recapitulate organ-level function. Given the …

The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …

Every year, cancer causes millions of deaths around the globe, and researchers have been
engaged to provide novel therapies for this threatening disease. However, this process is …

Cancer remains one of the leading causes of death, albeit enormous efforts to cure the
disease. To overcome the major challenges in cancer therapy, we need to have a better …

The interactions among tumour cells, the tumour microenvironment (TME) and non-tumour
tissues are of interest to many cancer researchers. Micro-engineering approaches and …

Tumors are a major cause of death worldwide, and much effort has been made to develop
appropriate anti-tumor therapies. Existing in vitro and in vivo tumor models cannot reflect the …

Tumors develop in intricate microenvironments required for their sustained growth, invasion,
and metastasis. The tumor microenvironment plays a critical role in the malignant or drug …

Tumour cell proliferation, metabolism and treatment response depend on the dynamic
interaction of the tumour cells with other cellular components and physicochemical gradients …