HLA class I–associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children

RA Porritt, L Paschold, MN Rivas… - The Journal of …, 2021 - Am Soc Clin Investig
Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory syndrome
associated with SARS-CoV-2 infection, shares clinical features with toxic shock syndrome …

Polyclonal expansion of TCR Vβ 21.3+ CD4+ and CD8+ T cells is a hallmark of multisystem inflammatory syndrome in children

M Moreews, K Le Gouge, S Khaldi-Plassart… - Science …, 2021 - science.org
Multisystem inflammatory syndrome in children (MIS-C) is a delayed and severe
complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

COVID-19–associated multisystem inflammatory syndrome in children (MIS-C): A novel disease that mimics toxic shock syndrome—the superantigen hypothesis

MN Rivas, RA Porritt, MH Cheng, I Bahar… - Journal of Allergy and …, 2021 - jacionline.org
As of mid-September, the novel severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has infected more than 30 million people, resulting in approximately 1 million deaths …

Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

K Sacco, R Castagnoli, S Vakkilainen, C Liu… - Nature medicine, 2022 - nature.com
Abstract Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a
minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS …

Pediatric inflammatory multisystem syndrome temporally related with SARS-CoV-2: immunological similarities with acute rheumatic fever and toxic shock syndrome

D Buonsenso, F Riitano, P Valentini - Frontiers in Pediatrics, 2020 - frontiersin.org
Several studies demonstrated that COVID-19 in children is a relatively mild disease.
However, recently a more serious condition characterized by systemic inflammation with …

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

MH Cheng, S Zhang, RA Porritt… - Proceedings of the …, 2020 - National Acad Sciences
Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 is a
newly recognized condition in children with recent severe acute respiratory syndrome …

[HTML][HTML] Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

A Ramaswamy, NN Brodsky, TS Sumida, M Comi… - Immunity, 2021 - cell.com
Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious
complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV-2 …

Multisystem inflammatory syndrome in children and long COVID: the SARS-CoV-2 viral superantigen hypothesis

M Noval Rivas, RA Porritt, MH Cheng, I Bahar… - Frontiers in …, 2022 - frontiersin.org
Multisystem inflammatory syndrome in children (MIS-C) is a febrile pediatric inflammatory
disease that may develop weeks after initial SARS-CoV-2 infection or exposure. MIS-C …

[HTML][HTML] TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

L Hoste, L Roels, L Naesens, V Bosteels… - Journal of Experimental …, 2022 - rupress.org
In rare instances, pediatric SARS-CoV-2 infection results in a novel immunodysregulation
syndrome termed multisystem inflammatory syndrome in children (MIS-C). We compared …

Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children

ND Beckmann, PH Comella, E Cheng, L Lepow… - Nature …, 2021 - nature.com
Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation
and pathology of multiple organs in individuals under 21 years of age in the weeks following …