Pancreatic beta cells play a central role in regulating glucose homeostasis by secreting the
hormone insulin. Failure of beta cells due to reduced function and mass and the resulting …

Pancreatic β cells secrete insulin in response to postprandial increases in glucose levels to
prevent hyperglycemia and inhibit insulin secretion under fasting conditions to protect …

Although genetic variations and environmental factors are vital to the development and
progression of type 2 diabetes mellitus (T2DM), emerging literature suggest that epigenetics …

DNA methylation at promoters is an important determinant of gene expression. Earlier
studies suggested that the insulin gene promoter is uniquely unmethylated in insulin …

In addition to genetic predisposition, environmental and lifestyle factors contribute to the
pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for …

Abstract Development of the human pancreas requires the precise temporal control of gene
expression via epigenetic mechanisms and the binding of key transcription factors. We …

Type 2 diabetes (T2D) develops due to insulin resistance and impaired insulin secretion,
predominantly in genetically predisposed subjects exposed to nongenetic risk factors like …

Although the factors responsible for the recent increase in the prevalence of diabetes
worldwide are not entirely known, the morbidity associated with this disease results in …

Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect
disease susceptibility. To describe the human methylome in pancreatic islets and determine …

Type 2 diabetes is a complex trait with both environmental and hereditary factors
contributing to the overall pathogenesis. One link between genes, environment, and disease …