Recent studies suggest that CD8+ T cells with down-regulated CD8 expression (CD3+ CD8
low T cells) represented as a distinct phenotype of CD8+ T cells are increased and linked to …

Objective To investigate the compositions of Th1/Th2/Th3 cells in chronic hepatitis B virus
(HBV)-infected individuals by determining the expression of interleukin-4 (IL-4), inetrferon-y …

The inflamed liver in chronic hepatitis B virus (HBV) infection (CHB) is characterized by a
large influx of non–virus-specific CD8 T cells. Little is known about the functional capacity of …

Abstract CD4+ T and regulatory T cells (Tregs) seem to play a key role in persistence of
hepatitis B virus (HBV) infection. However, the molecular events by which Tregs exert their …

Background Chronic HBV infection presents weak or no virus-specific T-cell responses,
implying to an exhausted phenotype, characterized by overexpression of several inhibitory …

Hepatitis B virus (HBV) infection is a major cause of chronic liver disease that may progress
to liver cirrhosis and hepatocellular carcinoma. Host immune responses represent the key …

Chronic hepatitis B (CHB) is one of the most common types of infectious diseases
worldwide. The interaction between hepatitis B virus (HBV) and the host immune response …

Background & Aims T cells play a critical role in viral infection. We examined whether T-cell
effector and regulatory responses can define clinical stages of chronic hepatitis B (CHB) …

Distinct populations of hepatocytes infected with hepatitis B virus (HBV) or only harboring
HBV DNA integrations coexist within an HBV chronically infected liver. These hepatocytes …

Background/Aims: The aim of this study is to clarify the differences of host immune
responses between acute self-limited and chronic persistent hepatitis B virus (HBV) …