Chronic hepatitis B virus (HBV) infection is characterized by a weak immune response to
HBV. Regulatory T cells (Treg) can suppress the function of effector T cells and may thus be …

ABSTRACT CD4+ CD25+ regulatory T cells have been shown to maintain peripheral
tolerance against self and foreign antigens. In this study we analyzed the effect of circulating …

Abstract Introduction: Regulatory T cells (Tregs) play a critical role in chronic viral infections.
The role of Tregs in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) is unknown …

Given the B helper function of follicular T helper (Tfh) cells and peripheral T helper (Tph)
cells, we researched the roles of circulating PD-1 hi CXCR5+ CD4+ T cells and PD-1 hi …

Background & Aims With or without antiviral treatment, few individuals achieve sustained
functional cure of chronic hepatitis B virus (HBV) infection. A better definition of what …

Chronic hepatitis B virus (HBV) infection is a complex disease with dysregulations in the
immune system. Follicular helper T (Tfh) cells are professional B helper cells that are crucial …

Hepatitis B virus (HBV)-specific CD8+ T cells play a dominant role during acute-resolving
HBV infection but are functionally impaired during chronic HBV infection in humans. These …

T follicular helper cells (Tfh) provide help to B cells to support their activation, expansion and
differentiation. However, the role of Tfh cells in chronic HBV infection is poorly defined. The …

Abstract Background Blood CXCR5+ CD4+ T cells are defined as circulating T follicular
helper (TFH) cells, which is required for effective humoral immunity. This study aimed to …

Background Liver cancer is the sixth most common cancer worldwide and the third leading
cause of cancer-related death. As a chronic liver disease, many studies have shown that the …