High antigen burden during chronic hepatitis B (CHB) results in a low frequency HBV-
specific T cell response with restricted functionality. However, this observation is based on …

Abstract Background and Aims Classical CD8 T cells are implicated for protective and
pathogenic roles in chronic hepatitis B (CHB) infection. Recently, a subset of CD8 T cells …

Methods A total of 83,577 T cells from HBV-ACLF patients and healthy controls were
screened for heterogeneity by single-cell RNA sequencing. In addition, exhausted T …

AIM: Persistent hepatitis B virus (HBV) infection is characterized by a weak CD8+ T cell
response to HBV. Immunotherapeutic strategies that overcome tolerance and boost these …

Summary Circulating CD4+ CD25+ regulatory T cells (Tregs) have been demonstrated to
maintain immunotolerance and suppress the antigen‐specific or antigen‐non‐specific T‐cell …

Objective The pathogenesis of hepatitis B virus (HBV)-associated chronic liver disease is
still not fully understood. The immune imbalance of cytokine profile exerts a profound …

Objective CD4 (+) CD25 (high) regulatory T cells (Treg) have been shown to play an
important role in maintaining peripheral tolerance against self and foreign antigens, and in …

Viral antigen-specific T cells are important for virus elimination. We studied the hepatitis B
virus (HBV)-specific T cell response using flow cytometry. Three phases of HBV infection …

AIM: To determine whether dendritic cells (DCs) from chronic hepatitis B patients could
induce HBV antigen-specific T cell responses or not. METHODS: DCs were generated from …

To investigate the correlation between the HBeAg and the properties of HBV-specific CD8 T
cells, as well as liver injury, serum HBV markers, liver histology, the frequency and …