Chronic hepatitis B (CHB) is characterized by functionally impaired virus‐specific CD 8+ T‐
cell responses. However, the mechanism underlying this dysfunction has not been fully …

T-cell immunoglobulin domain and mucin domain-containing molecule-3 (Tim-3) was up-
regulated on viral specific T cells and contributed to T cells exhaustion during chronic …

To evaluate the inhibition of CD4+ CD25+ regulatory T cells (Treg) in the chronic hepatitis B
patients. Peripheral blood samples were collected from 22 patients with chronic hepatitis B …

Background & Aims There is an unclear relationship between inhibitory receptor expression
on T cells and their ability to control viral infections. Studies of human immune cells have …

Hepatitis B virus (HBV) is a noncytopathic virus, and the recognition of infected hepatocytes
by HBV-specific CD8 cells has been assumed to be the central mechanism causing both …

Chronic activity of hepatitis B is thought to involve aberrant immune tolerance of unknown
mechanism. In this study, we examined the role of CD4+ CD25+ Foxp3+ regulatory T cells in …

B cells play an important role in the clearance of hepatitis B virus (HBV) and protection
against reinfection. However, the functional characteristics of these cells that are associated …

BACKGROUND Chronic hepatitis B is a highly heterogeneous disease that can be divided
into four phases: Immune tolerant (IT), immune active (IA), inactive carrier (IC) and hepatitis …

The antiviral response of natural killer (NK) cells and CD8+ T cells is weak in patients with
chronic hepatitis B (CHB) infection. However, the specific characteristics of these cells and …

Background T-cell exhaustion seems to play a critical role in CD8+ T-cell dysfunction during
chronic viral infections. However, up to now little is known about the mechanisms underlying …