Background T-cell exhaustion seems to play a critical role in CD8+ T-cell dysfunction during
chronic viral infections. However, up to now little is known about the mechanisms underlying …

T lymphocytes are the most important immune cells that affect both the development and
treatment of hepatitis B. We used high‐throughput sequencing to determine the diversity in …

Background & Aims CD8+ T cells are an essential component of a successful immune
response against hepatitis B virus (HBV). Patients who spontaneously clear HBsAg after …

We aimed to identify key genes and pathways associated with different immune statuses of
hepatitis B virus (HBV) infection. The gene expression and DNA methylation profiles were …

During chronic hepatitis B (CHB), CD8+ T cells down-regulate CD28, the primary co-
stimulation molecule for T-cell activation. Diverse functional attributes of CD8+ CD28− T …

Chronic hepatitis B virus (HBV) infection is a major global health burden affecting around
257 million people worldwide. The consequences of chronic HBV infection include …

Hepatitis B virus exposure in children usually develops into chronic hepatitis B (CHB).
Although hepatitis B surface antigen (HBsAg)–specific CD8+ T cells contribute to resolve …

The extent to which T‑cell‑mediated immunity is impaired in patients with hepatitis B virus
(HBV) infection remains controversial. In addition, the role of T regulatory (Treg) and T …

Hepatitis B virus (HBV) remains a leading cause of liver-related morbidity and mortality
through chronic hepatitis that may progress to liver cirrhosis and cancer. The central role …

Chronic hepatitis B virus (HBV) infection is associated with functionally impaired virus-
specific T cell responses. Although the myeloid-derived suppressor cells (MDSCs) are …