[HTML][HTML] Gene therapy clinical trials, where do we go? An overview

F Arabi, V Mansouri, N Ahmadbeigi - Biomedicine & Pharmacotherapy, 2022 - Elsevier
There have been many ups and downs since the introduction of gene therapy as a
therapeutic modality for diseases. However, the journey of gene therapy has reached a …

Gene therapy clinical trials worldwide to 2012–an update

SL Ginn, IE Alexander, ML Edelstein… - The journal of gene …, 2013 - Wiley Online Library
To date, over 1800 gene therapy clinical trials have been completed, are ongoing or have
been approved worldwide. Our database brings together global information on gene therapy …

Gene therapy clinical trials worldwide to 2017: An update

SL Ginn, AK Amaya, IE Alexander… - The journal of gene …, 2018 - Wiley Online Library
To date, almost 2600 gene therapy clinical trials have been completed, are ongoing or have
been approved worldwide. Our database brings together global information on gene therapy …

The era of gene therapy: From preclinical development to clinical application

NA Alhakamy, DT Curiel, CJ Berkland - Drug discovery today, 2021 - Elsevier
Three decades of promise have culminated in the development of gene therapies that can
be applied to a broad range of human diseases. After a brief history, we provide an overview …

Entering the modern era of gene therapy

XM Anguela, KA High - Annual review of medicine, 2019 - annualreviews.org
Gene therapies are gaining momentum as promising early successes in clinical studies
accumulate and examples of regulatory approval for licensing increase. Investigators are …

Gene therapy clinical trials worldwide to 2007—an update

ML Edelstein, MR Abedi, J Wixon - The Journal of Gene …, 2007 - Wiley Online Library
To date, over 1340 gene therapy clinical trials have been completed, are ongoing or have
been approved worldwide. In 1997 we set up a database to bring together global …

Gene therapies development: slow progress and promising prospect

E Hanna, C Rémuzat, P Auquier, M Toumi - Journal of market access & …, 2017 - mdpi.com
Background: In 1989, the concept of human gene therapies has emerged with the first
approved human gene therapy trial of Rosenberg et al. Gene therapies are considered as …

Development and clinical translation of approved gene therapy products for genetic disorders

A Shahryari, M Saghaeian Jazi, S Mohammadi… - Frontiers in …, 2019 - frontiersin.org
The field of gene therapy is striving more than ever to define a path to the clinic and the
market. Twenty gene therapy products have already been approved and over two thousand …

[HTML][HTML] Gene therapy, early promises, subsequent problems, and recent breakthroughs

SR Soofiyani, B Baradaran, F Lotfipour… - Advanced …, 2013 - ncbi.nlm.nih.gov
Gene therapy is one of the most attractive fields in medicine. The concept of gene delivery to
tissues for clinical applications has been discussed around half a century, but scientist's …

Gene therapy for cancer: regulatory considerations for approval

SR Husain, J Han, P Au, K Shannon, RK Puri - Cancer gene therapy, 2015 - nature.com
The rapidly changing field of gene therapy promises a number of innovative treatments for
cancer patients. Advances in genetic modification of cancer and immune cells and the use of …