The regulation of early events in mammalian embryonic development is a complex process.
In the early stages, pluripotency, cellular differentiation, and growth should occur at specific …

In the areas of developmental biology and embryonic stem cell research, reliable molecular
markers of pluripotency and early lineage commitment are sparse in large animal species. In …

The present study examined the activity and function of the pig OCT4 enhancer in the
porcine early embryonic development stage and porcine authentic embryonic stem cells …

The signaling mechanisms regulating pluripotency in porcine embryonic stem cells and
embryos are unknown. In this study, we characterize cell signaling in the in‐vivo porcine …

Simple Summary The fusion between sperm and oocyte results in a zygote, which is a single
totipotent cell with the ability to develop into a functional organism. Totipotent cells can give …

The objective of this study was to determine the expression patterns of the pluripotency-
determining factors, Oct-4 and Nanog, in pre-implantation goat embryos. The POU octamer …

Mammalian development relies on the cellular proliferation and precisely orchestrated
differentiation processes. In preimplantation embryos preservation of the pluripotent state …

Pluripotency genes are implicated in mouse embryonic genome activation (EGA) and
pluripotent lineage specification. Moreover, their expression levels have been correlated …

Unlike in mice, the function of pluripotent markers in early embryonic development of
domestic animals remains to be elucidated and this may account for the failure to establish …

Mouse embryonic stem cells (ESC), derived from preimplantation embryos in 1981, defined
mammalian pluripotency for many decades. However, after the derivation of human ESC in …