Role of human AADAC on hydrolysis of eslicarbazepine acetate and effects of AADAC genetic polymorphisms on hydrolase activity
K Hirosawa, T Fukami, K Tashiro, Y Sakai, F Kisui… - Drug Metabolism and …, 2021 - ASPET
Human arylacetamide deacetylase (AADAC) plays a role in the detoxification or activation of
drugs and is sometimes involved in the incidence of toxicity by catalyzing hydrolysis …
drugs and is sometimes involved in the incidence of toxicity by catalyzing hydrolysis …
Role of human arylacetamide deacetylase (AADAC) on hydrolysis of eslicarbazepine acetate and effects of AADAC genetic polymorphisms on hydrolase activity
K Hirosawa, T Fukami, K Tashiro, Y Sakai, F Kisui… - Drug Metabolism and …, 2021 - ASPET
Human arylacetamide deacetylase (AADAC) plays a role in the detoxification or activation of
drugs and is sometimes involved in the incidence of toxicity by catalyzing hydrolysis …
drugs and is sometimes involved in the incidence of toxicity by catalyzing hydrolysis …
Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases
T Fukami, M Kariya, T Kurokawa, A Iida… - European Journal of …, 2015 - Elsevier
Human arylacetamide deacetylase (AADAC) is an esterase responsible for the hydrolysis of
some drugs, including flutamide, indiplon, phenacetin, and rifamycins. AADAC is highly …
some drugs, including flutamide, indiplon, phenacetin, and rifamycins. AADAC is highly …
A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity
M Shimizu, T Fukami, Y Kobayashi, M Takamiya… - Drug Metabolism and …, 2012 - ASPET
Human arylacetamide deacetylase (AADAC) is responsible for the hydrolysis of clinically
used drugs such as flutamide, phenacetin, and rifamycins. Our recent studies suggested that …
used drugs such as flutamide, phenacetin, and rifamycins. Our recent studies suggested that …
Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse
Y Kobayashi, T Fukami, A Nakajima, A Watanabe… - Drug Metabolism and …, 2012 - ASPET
Human arylacetamide deacetylase (AADAC) is a major esterase responsible for the
hydrolysis of clinical drugs such as flutamide, phenacetin, and rifampicin. Thus, AADAC is …
hydrolysis of clinical drugs such as flutamide, phenacetin, and rifampicin. Thus, AADAC is …
ABCB1 C3435T, G2677T/A and C1236T variants have no effect in eslicarbazepine pharmacokinetics
M Peso-Casado, D Ochoa… - Biomedicine & … - repositorioinstitucional.ceu.es
Eslicarbazepine acetate is a third-generation anti-epileptic prodrug quickly and extensively
transformed to eslicarbazepine after oral administration. Reduction in seizure frequency in …
transformed to eslicarbazepine after oral administration. Reduction in seizure frequency in …
[HTML][HTML] ABCB1 C3435T, G2677T/A and C1236T variants have no effect in eslicarbazepine pharmacokinetics
P Zubiaur, M del Peso-Casado, D Ochoa… - Biomedicine & …, 2021 - Elsevier
Eslicarbazepine acetate is a third-generation anti-epileptic prodrug quickly and extensively
transformed to eslicarbazepine after oral administration. Reduction in seizure frequency in …
transformed to eslicarbazepine after oral administration. Reduction in seizure frequency in …
Arylacetamide deacetylase enzyme: presence and interindividual variability in human lungs
M Gabriele, P Puccini, M Lucchi, V Aprile… - Drug Metabolism and …, 2019 - ASPET
Human arylacetamide deacetylase (AADAC) is a single microsomal serine esterase
involved in the hydrolysis of many acetyl-containing drugs. To date, the presence and …
involved in the hydrolysis of many acetyl-containing drugs. To date, the presence and …
Indiplon is hydrolyzed by arylacetamide deacetylase in human liver
M Shimizu, T Fukami, Y Ito, T Kurokawa, M Kariya… - Drug Metabolism and …, 2014 - ASPET
Human arylacetamide deacetylase (AADAC) catalyzes the hydrolysis of some clinically used
drugs, but the information available on its substrates is limited. To increase our knowledge of …
drugs, but the information available on its substrates is limited. To increase our knowledge of …
Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase
K Yasuda, K Watanabe, T Fukami, S Nakashima… - Drug Metabolism and …, 2021 - Elsevier
Recently, in addition to carboxylesterases (CESs), we found that arylacetamide deacetylase
(AADAC) plays an important role in the metabolism of some clinical drugs. In this study, we …
(AADAC) plays an important role in the metabolism of some clinical drugs. In this study, we …