Restoration of ceramide de novo synthesis by the synthetic retinoid ST1926 as it induces adult T-cell leukemia cell death
B Ghandour, C Pisano, N Darwiche… - Bioscience …, 2020 - portlandpress.com
Ceramide (Cer) is a bioactive cellular lipid with compartmentalized and tightly regulated
levels. Distinct metabolic pathways lead to the generation of Cer species with …
levels. Distinct metabolic pathways lead to the generation of Cer species with …
Dynamics of ceramide generation and metabolism in response to fenretinide–Diversity within and among leukemia
SAF Morad, TS Davis, M Kester, TP Loughran Jr… - Leukemia research, 2015 - Elsevier
Abstract Fenretinide, N-(4-hydroxyphenyl) retinamide,(4-HPR), a synthetic retinoid, owes its
cancer-toxic effects in part to the generation of ceramide, a potent tumor-suppressing …
cancer-toxic effects in part to the generation of ceramide, a potent tumor-suppressing …
[HTML][HTML] C22: 0-and C24: 0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines
We previously reported that fenretinide (4-HPR) was cytotoxic to acute lymphoblastic
leukemia (ALL) cell lines in vitro in association with increased levels of de novo synthesized …
leukemia (ALL) cell lines in vitro in association with increased levels of de novo synthesized …
Dihydroceramide desaturases are differentially expressed in Fenretinide-resistant pediatric Acute Lymphoblastic Leukemia (ALL) cell lines
J Wu, BJ Maurer - Cancer Research, 2006 - AACR
Abstract 1257 Drug resistance to chemotherapy is a major obstacle to the treatment of
primarily refractory and relapsed pediatric acute lymphoblastic leukemias (ALL). The …
primarily refractory and relapsed pediatric acute lymphoblastic leukemias (ALL). The …
Caspase-dependent and-independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs
Ceramide metabolism has emerged as a potential target for anticancer therapy. Here, the
potential usefulness of two novel synthetic ceramide analogs as anti-leukemic drugs was …
potential usefulness of two novel synthetic ceramide analogs as anti-leukemic drugs was …
Human T-cell lymphotropic virus type I-transformed T-cells have a partial defect in ceramide synthesis in response to N-(4-hydroxyphenyl)retinamide
N Darwiche, G Abou-Lteif, T Najdi… - Biochemical …, 2005 - portlandpress.com
Treatment with the synthetic retinoid HPR [N-(4-hydroxyphenyl)-retinamide] causes growth
arrest and apoptosis in HTLV-I (human T-cell lymphotropic virus type-I)-positive and HTLV-I …
arrest and apoptosis in HTLV-I (human T-cell lymphotropic virus type-I)-positive and HTLV-I …
Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death
A Apraiz, J Idkowiak-Baldys… - … and Cell Biology, 2012 - cdnsciencepub.com
4-(Hydroxyphenyl) retinamide (4-HPR) is a synthetic retinoid with a strong apoptotic effect
towards different cancer cell lines in vitro, and it is currently tested in clinical trials. Increases …
towards different cancer cell lines in vitro, and it is currently tested in clinical trials. Increases …
[HTML][HTML] Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens
AD Tepper, SH Diks, WJ van Blitterswijk… - Journal of Biological …, 2000 - ASBMB
Ceramide (Cer) accumulating during the execution phase of apoptosis is generated from
plasma membrane sphingomyelin (SM), which gains access to a sphingomyelinase due to …
plasma membrane sphingomyelin (SM), which gains access to a sphingomyelinase due to …
Cell cycle arrest of hematopoietic cell lines after treatment with ceramide is commonly associated with retinoblastoma activation
CE Connor, J Burrows, AC Hearps… - … : The Journal of the …, 2001 - Wiley Online Library
Background Leukaemia cells differ from their normal counterparts in that their ability to
properly regulate survival, proliferation, differentiation, and apoptosis is aberrant …
properly regulate survival, proliferation, differentiation, and apoptosis is aberrant …
[HTML][HTML] Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia
D Verlekar, SJ Wei, H Cho, S Yang, MH Kang - Cell death & disease, 2018 - nature.com
Ceramide synthases (CERS) produce ceramides which are key intermediators in the
biosynthesis of complex sphingolipids and play an important role in cell proliferation …
biosynthesis of complex sphingolipids and play an important role in cell proliferation …