A series of substituted isoquinolinones were synthesized and their binding affinities and
functional activities towards human melatonin MT1 and MT2 receptors were evaluated …

Melatonin MT 1 and MT 2 receptors represent attractive drug targets for the treatment of
various disorders. However, the high conservation of the melatonin binding pocket has …

Molecular superposition models guided the design of novel melatonin receptor ligands
characterized by a 2-acylaminomethyltetrahydroquinoline scaffold. Starting from the …

Two novel series of melatonin-derived compounds have been synthesized and
pharmacologically evaluated at the MT1 and MT2 subtypes of melatonin receptors …

A number of 6-methoxy-1-(2-propionylaminoethyl) indoles, carrying properly selected
substituents at the C-2 indole position, were prepared and tested as melatonin receptor …

The synthesis of novel melatonin analogues 3a and 4a–c designed as melatonin receptor
ligands is described. Among the newly synthesized ligands, 2-((S)-2-hydroxymethylindolin-1 …

A series of substituted N-[3-(3-methoxyphenyl) propyl] amides were synthesized and their
binding affinities towards human melatonin MT1 and MT2 receptors were evaluated. It was …

A series of N-(2-phenylbenzofuran-3-yl) ethyl amide and N-(2-arylalkylbenzofuran-3-yl) ethyl
amide derivatives were synthesized and evaluated as melatonin receptor ligands. The …

A series of chiral heterocyclic aminopyrrolidine derivatives was synthesized as novel
melatoninergic ligands. Binding affinity assays were performed on cloned human MT1 and …

Melatonin is a widely distributed hormone that regulates several major physiological
processes, including the circadian rhythm and seasonal adaptation. The two subtypes of …