Metabolic memory, the persistent benefits of early glycaemic control on preventing and/or
delaying the development of diabetic complications, has been observed in the Diabetes …

We examined whether persistence of epigenetic DNA methylation (DNA-me) alterations at
specific loci over two different time points in people with diabetes are associated with …

Epigenetic regulation has been postulated to affect glucose metabolism, insulin sensitivity
and the risk of type 2 diabetes. Therefore, we performed an epigenome-wide association …

DNA methylation (DNAm) has been found to show robust and widespread age-related
changes across the genome. DNAm profiles from whole blood can be used to predict human …

Macrovascular complications such as atherosclerosis, myocardial infarction and stroke, and
microvascular complications such as nephropathy, retinopathy, and neuropathy are the …

Aims/hypothesis Development of type 2 diabetes depends on environmental and genetic
factors. We investigated the epigenome-wide association of prevalent diabetes with DNA …

Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and
obesity, our understanding of its functional relevance remains limited. Here we show the …

Background Type 2 diabetes mellitus (T2D) is highly prevalent in Middle-Eastern and North
African Arab populations, but the molecular basis for this susceptibility is unknown. Altered …

The prevalence of diabetes (DM) is constantly increasing worldwide at an alarming rate.
According to the International Diabetes Federation in 2015, an estimated 415 million people …

Aims/hypothesis Epigenetic mechanisms may play an important role in the aetiology of type
2 diabetes. Recent epigenome-wide association studies (EWASs) identified several DNA …