Oligonucleotides used in gene therapy and silencing are fragile compounds that degrade
easily in biological environments. Porous biocompatible carrier particles may provide a …

Mesoporous silica nanoparticle (MSN) is a promising material for biomedical applications,
such as delivering drugs or biological molecules (siRNA or DNA), to the target cells or …

Mesoporous silica nanoparticles have attracted much attention in recent years as drug and
gene delivery systems for biomedical applications. Among their most beneficial features for …

Gene therapy is a promising strategy for treatment of genetically caused diseases.
Successful gene delivery requires an efficient carrier to transfer the desired gene into host …

Efforts are being made to develop gene therapy delivery systems capable of substituting the
viral vectors with comparable efficiency but with fewer biosafety concerns, easier production …

Silencing genes using small interfering (si) RNA is a promising strategy for treating cancer.
However, the curative effect of siRNA is severely constrained by low serum stability and cell …

Mesoporous silica nanoparticles have been synthesized and functionalized with four
different types of molecules containing amino groups, ie, with primary amines only, with …

Several nanocomposites based on Mesoporous Silica Nanoparticles (MSN), aluminum ions,
and Polyethyleneimine (PEI) were synthesized by the combination of the sol-gel and post …

Using the sol-gel method, mesoporous silica (MPS) was successfully hybridized with PEI
and PEG polymers and encapsulated RNA oligonucleotides in one pot, at a single step …

Effective gene delivery system plays an importmant role in the gene therapy. Mesoporous
silica nanoparticle (MSN) has become one potential gene delivery vector because of its high …