The use of nucleic acid to control the expression of genes relevant to tumor progression is a
key therapeutic approach in cancer research. Therapeutics based on nucleic acid provide …

Combination therapies rely on the administration of more than one drug, with independent
mechanisms of action, aiming to enhance the efficiency of the treatment. For an optimal …

A new general route for siRNA delivery is presented combining porous core–shell silica
nanocarriers with a modularly designed multifunctional block copolymer. Specifically, the …

The technology of RNA interference (RNAi) that uses small interfering RNA (siRNA) to
silence the gene expression with complementary messenger RNA (mRNA) sequence has …

Mesoporous silica nanoparticles (MSNPs) are functionalized with molecular‐recognition
sites by anchoring a triazine or uracil fragment on the surface. After loading these MSNPs …

Mesoporous silica nanoparticles (MSN) were functionalized with aminopropyltriethoxysilane
(MSN-NH 2) then l-histidine (MSN-His) for pDNA delivery in cells and in vivo. The …

Mesoporous silica nanoparticles (MSN) have been explored for the delivery of small
molecule drugs, antigens, and nucleic acids because of their large surface area, pore …

For efficacious gene therapeutics, cytosolic transport of the endocytosed siRNA is crucial,
not to mention a non-toxic delivery carrier composition. In this paper, we report facile …

Pharmaceutics | Free Full-Text | Mesoporous Organosilica Nanoparticles with Tetrasulphide
Bond to Enhance Plasmid DNA Delivery Next Article in Journal In Silico Pharmacology for …

We have developed tailor-designed mesoporous silica nanoparticles (MSNPs) specifically
for delivering mRNA. Our unique assembly protocol involves premixing mRNA with a …