Poly-adenine DNA as the high-affinity goalkeeper of mesoporous silica nanoparticles for molecular encapsulation and signal-amplification detection

W He, K Huang - Surfaces and Interfaces, 2021 - Elsevier
The adsorption of DNA on the surface is the basic task of mesoporous silica nanoparticles
(MSN) because of its surface charge characteristics. Therefore, without covalent …

Adsorption and release of siRNA from porous silica

JL Steinbacher, CC Landry - Langmuir, 2014 - ACS Publications
Porous silica particles are potential transfection agents for nucleic acid-based therapies
because of their large specific surface areas and pore volumes and the ease with which they …

A DNA transporter based on mesoporous silica nanospheres mediated with polycation poly (allylamine hydrochloride) coating on mesopore surface

F Qin, Y Zhou, J Shi, Y Zhang - … Part A: An Official Journal of …, 2009 - Wiley Online Library
Mesoporous silica nanospheres (MPNSs) were synthesized by the sol–gel method and
were investigated by X‐ray diffraction, nitrogen sorption, and transmission electron …

A triple-layer design for polyethyleneimine-coated, nanostructured magnetic particles and their use in DNA binding and transfection

HHP Yiu, SC McBain, AJ El Haj, J Dobson - Nanotechnology, 2007 - iopscience.iop.org
Nanostructured iron oxide–silica particles have been prepared using SBA-15 mesoporous
silica particles as a template. Iron oxide nanoparticles were impregnated inside the …

Anisotropic silica mesostructures for DNA encapsulation

A Ganguly, AK Ganguli - Bulletin of Materials Science, 2013 - Springer
The encapsulation of biomolecules in inert meso or nanostructures is an important step
towards controlling drug delivery agents. Mesoporous silica nanoparticles (MSN) are of …

Periodic Mesoporous Ionosilica Nanoparticles for BODIPY Delivery and Photochemical Internalization of siRNA

B Mezghrani, LMA Ali, S Jakimoska, F Cunin… - …, 2023 - Wiley Online Library
Abstract Periodic Mesoporous Ionosilica Nanoparticles (PMINPs) made via co‐
condensation reactions starting from an ionosilica precursor and a porphyrin derivative were …

Design of mesoporous silica/cytosine− phosphodiester− guanine oligodeoxynucleotide complexes to enhance delivery efficiency

Y Zhu, W Meng, X Li, H Gao… - The Journal of Physical …, 2011 - ACS Publications
We developed a potential cytosine− phosphodiester− guanine oligodeoxynucleotide (CpG
ODN) delivery system combining amino-modified mesoporous silica SBA-15 (SBA-NH2) …

Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer

L Sun, D Wang, Y Chen, L Wang, P Huang, Y Li, Z Liu… - Biomaterials, 2017 - Elsevier
The design and synthesis of hierarchically nanoporous structures for the co-encapsulation
and sequential releases of different cargos are still great challenges in biomedical …

A redox-responsive strategy using mesoporous silica nanoparticles for co-delivery of siRNA and doxorubicin

S Zhao, M Xu, C Cao, Q Yu, Y Zhou… - Journal of materials …, 2017 - pubs.rsc.org
Co-delivery of gene and drug therapies for cancer treatment remains a major goal of
nanocarrier research. In this study, mesoporous silica nanoparticles (MSNs) were used to co …

[引用][C] Designed synthesis of silica based nanocarriers for mRNA delivery

Y Wang - 2020 - espace.library.uq.edu.au
In recent decades, introducing messenger RNA (mRNA) into cells has garnered intense
interest for diverse applications. Limited by the short half-life and cell-membrane …