Cyclooxygenases-2 (COX-2) and Prostaglandin E2 (PGE2), which are important in chronic
inflammatory diseases, can increase tumor incidence and promote tumor growth and …

The clinical application of immunotherapy is the milestone of cancer treatment. However,
some patients have bad reaction. Cyclooxygenase-2 (COX-2) is frequently expressed in …

Abstract Cyclooxygenase-2 (COX-2), an inducible form of the enzyme that catalyzes the first
step in the synthesis of prostanoids, is associated with inflammatory diseases and …

A highly expressed prostaglandin E2 (PGE2) in tumor tissues suppresses antitumor
immunity in the tumor microenvironment (TME) and causes tumor immune evasion leading …

Simple Summary Inflammation is assessed as a hallmark of cancer and it is now widely
recognized that there exists a direct causal link between inflammation and tumors. Among …

The mechanisms by which melanoma and other cancer cells evade anti-tumor immunity
remain incompletely understood. Here, we show that the growth of tumors formed by mutant …

Tumor-associated inflammation can create an immunosuppressive microenvironment
allowing tumor cells to escape immunosurveillance. Inhibiting immunosuppression remains …

Cytotoxic therapies, besides directly inducing cancer cell death, can stimulate immune-
dependent tumor growth control or paradoxically accelerate tumor progression. The …

Cyclooxygenase-2 is frequently upregulated in epithelial tumors and contributes to poor
outcomes in multiple malignancies. The COX-2 product prostaglandin E2 (PGE2) promotes …

The number of colorectal cancer (CRC) patients is increasing worldwide. Accumulating
evidence has shown that the tumor microenvironment (TME), including macrophages …