The role of Aurora B kinase in normal and cancer cells

E Titova, G Shagieva, V Dugina, P Kopnin - Biochemistry (Moscow), 2023 - Springer
Aurora kinases are essential players in mammalian cell division. These kinases are involved
in the regulation of spindle dynamics, microtubule–kinetochore interactions, and …

Mitotic failures in cancer: Aurora B kinase and its potential role in the development of aneuploidy

K Hegyi, G Méhes - Pathology & Oncology Research, 2012 - Springer
One of the basic requirements during the process of cell division is to maintain genetic
integrity and ensure normal ploidy. The family of Aurora kinases, composed of Aurora A, B …

[PDF][PDF] Aurora kinases: structure, functions and their association with cancer.

M Kollareddy, P Dzubak, D Zheleva… - Biomedical Papers of …, 2008 - biomed.papers.upol.cz
Background: Aurora kinases are a recently discovered family of kinases (A, B & C)
consisting of highly conserved serine\threonine protein kinases found to be involved in …

Aurora kinases as an anti-cancer target

T Ikezoe - Cancer letters, 2008 - Elsevier
The Aurora family of serine/threonine kinases plays an important role in chromosome
alignment, segregation and cytokinesis during mitosis. Recent studies have found aberrant …

Aurora-A—a guardian of poles

T Marumoto, D Zhang, H Saya - Nature Reviews Cancer, 2005 - nature.com
The three human homologues of Aurora kinases (A, B and C) are essential for proper
execution of various mitotic events and are important for maintaining genomic integrity …

The Aurora kinase family in cell division and cancer

G Vader, SMA Lens - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2008 - Elsevier
The Aurora protein kinase family (consisting of Aurora-A,-B and-C) is an important group of
enzymes that controls several aspects of cell division in mammalian cells. Dysfunction of …

Clinical experience with aurora kinase inhibitors: a review

DS Boss, JH Beijnen, JHM Schellens - The oncologist, 2009 - academic.oup.com
The aurora kinase family of serine/threonine kinases comprises three members, designated
auroras A, B, and C. Auroras A and B are essential components of the mitotic pathway …

Aurora kinases: new targets for cancer therapy

RD Carvajal, A Tse, GK Schwartz - Clinical cancer research, 2006 - AACR
The Aurora kinase family is a collection of highly related serine/threonine kinases that
functions as a key regulator of mitosis. In mammalian cells, Aurora has evolved into three …

Aurora B: a new prognostic marker and therapeutic target in cancer

G Portella, C Passaro, P Chieffi - Current medicinal chemistry, 2011 - ingentaconnect.com
Aurora B is a serine-threonine kinase belonging to the highly conserved Aurora family of
mitotic kinases. Aurora B is a chromosomal passenger protein involved in chromosome …

Aurora B: A new promising therapeutic target in cancer

P Chieffi - Intractable & rare diseases research, 2018 - jstage.jst.go.jp
A critical step for maintenance of genetic stability is chromosome segregation, which
requires a high coordination of cellular processes. Loss of mitotic regulation is a possible …