Inactivating mutations of the adenomatous polyposis coli (APC) gene and consequential
upregulation of the Wnt signaling pathway are critical initiators in the development of …

Colorectal cancer (CRC) is one of the most common forms of solid tumors in the world with
high rates of mortality and morbidity. Most cases of CRCs are initiated by inactivating …

The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis
and in most sporadic colorectal tumors. During both embryonic and postnatal periods, APC …

Introduction: The treatment of patients with advanced colorectal cancer still remains
challenging, and identification of new target molecules and therapeutic avenues remains a …

Inactivating mutations of the tumor suppressor Adenomatosis Polyposis Coli (APC), which
are found in familial adenomatosis polyposis and in 80% of sporadic colorectal cancers …

The Adenomatous Polyposis Coli (APC) tumor suppressor is most commonly mutated in
colorectal cancers such as familial adenomatous polyposis (FAP); as well as many other …

Aberrant Wnt/β-catenin signaling following loss of the tumor suppressor adenomatous
polyposis coli (APC) is thought to initiate colon adenoma formation. Considerable evidence …

Mutations in the adenomatous polyposis coli (APC) gene are common in colorectal cancer
(CRC), and more than 90% of those mutations generate stable truncated gene products. We …

Mutations in the adenomatous polyposis coli (APC) gene are the basis of familial
adenomatous polyposis and the majority of sporadic colorectal cancer. APC is expressed in …

Wnt signaling pathway activation via mutation of genetic components, commonly
adenomatous polyposis coli (APC), has a major role in colorectal cancer (CRC). Most …