The present research aimed to synthesize ketoprofen prodrugs and to demonstrate their
potentiality for oral treatment to treat chronic inflammation by reducing its hepatotoxicity and …

Prompted by the ineptness of the currently used non-steroidal antiinflammatory drugs
(NSAIDs) to control gastric mucosal and renal adverse reactions, several ester prodrugs of …

In silico molecular docking is an efficient technique for drug design that predicts the
optimized orientation of the ligand against a specific drug target. This is a cost-effective and …

Herein, we report the synthesis of four new hybrid molecules between ketoprofen or 2-(3-
benzoylphenyl) propanoic acid and N-containing heterocyclic compounds, such as …

Dexibuprofen–antioxidant conjugates were synthesized with the aim to reduce its
gastrointestinal effects. The esters analogs of dexibuprofen 5a–c were obtained by reacting …

Naproxen (NAP) is one of the commonly used nonselective Cycloxygenase (COX) inhibitors.
It is a choice of drug for anti-inflammatory activity by subsiding the generation of the …

The effect of 35 newly synthesized O-ethylmenthol (MET) derivatives on percutaneous
absorption of ketoprofen was investigated in rats. In order to understand the relationship …

Flurbiprofen–antioxidant mutual prodrugs were synthesized to reduce the gastrointestinal
(GI) effects associated with flurbiprofen. For reducing the GI toxicity, the free carboxylic group …

Background: The use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) is not up to its
potential because of their gastrointestinal side effects. Significant attention has been focused …

Inflammation is a complex reaction involving cellular and molecular components and an
unspecific response to a specific aggression. The use of scientific and technological …