Background: The effectiveness and safety of balanced crystalloid fl uids compared with
saline (0.9% sodium chloride) as a fl uid of choice in critically ill patients remain unclear. The …

Intravenous fluid therapy is the most common intervention received by acutely ill patients.
Historically, saline (0.9% sodium chloride) has been the most frequently administered …

Background: The optimal resuscitative fluid remains controversial. Objective: To assess the
association between crystalloid fluid and outcomes in critically ill adults. Methods …

Background The effect of balanced crystalloids compared with that of saline in critically ill
patients overall and in specific subgroups is unclear. We aimed to assess whether use of …

Background The comparative efficacy and safety of balanced crystalloid solutions and saline
for fluid therapy in critically ill adults remain uncertain. Methods We systematically reviewed …

Introduction Fluid resuscitation is a fundamental component of the management of critically
ill patients, but whether choice of crystalloid affects patient outcomes remains controversial …

Background Kidney transplant recipients often receive large volumes of intravenous fluid
replacement in the peri-operative period. Administration of 0.9% saline has previously been …

Background Prior studies in critically ill patients suggest the supra-physiologic chloride
concentration of 0.9%(“normal”) saline may be associated with higher risk of renal failure …

Fluid management has been a vital part of routine clinical care for more than 180 years. The
increasing number of available fluids has generated controversy about the optimal choice of …

Background The evidence regarding optimal crystalloid use in the perioperative period
remains unclear. As the primary aim of this study, we sought to summarise the data from …