Background Liver transplantation (LT) is the only effective radical cure for all types of end-
stage liver diseases. Major advances have been made in the field of liver transplantation …

Background Liver transplantation (LT) is the only effective radical cure for all types of end
stage liver diseases. Major advances have been made in the field of liver transplantation …

Objective: To evaluate the possible association of ABCB1 single nucleotide polymorphism
(SNPs) of the ABCB1 gene with tacrolimus dosages, concentration-to-dose ratios (CDR) and …

Objective Tacrolimus is an immunosuppressive drug widely used in hepatic transplantation
to avoid graft rejection. Its pharmacokinetics is characterized by a large interindividual …

BACKGROUND: The calcineurin inhibitor tacrolimus is widely used to prevent allograft
rejection after liver transplantation. It has a narrow therapeutic index and shows …

Background: Tacrolimus (TAC) is an immunosuppressant used in organ transplant
recipients. It is a substrate of drug transporter ABCB1 as well as of cytochrome P4503A …

The aim of this study was to investigate whether the heterogeneity in tacrolimus dose
requirement is associated with ABCB1 and CYP3A5 gene polymorphisms in Chinese liver …

Purpose. The effect of ABCB1 3435C> T on tacrolimus concentrations in liver transplant
recipients was studied. Tacrolimus is a substrate for P-glycoprotein, the product of the …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Currently tacrolimus is the mainstay
of immunosuppression for most children undergoing liver transplantation (LT).• The clinical …

Objectives The effect of ABCB1 C3435T SNP on the pharmacokinetics of
immunosuppressive drug tacrolimus in different studies was conflicting. So a meta-analysis …