Impact of ABCB1 (MDR1) haplotypes on tacrolimus dosing in adult lung transplant patients who are CYP3A5* 3/* 3 nonexpressors
J Wang, A Zeevi, K McCurry, E Schuetz, HX Zheng… - Transplant …, 2006 - Elsevier
BACKGROUND: The influence of ABCB1 (MDR1) polymorphisms on tacrolimus dosing has
been questioned in previous studies with contradictory findings, possibly due to the …
been questioned in previous studies with contradictory findings, possibly due to the …
Impact of CYP3A7, CYP2D6 and ABCC2/ABCC3 polymorphisms on tacrolimus steady state concentrations in Bulgarian kidney transplant recipients
T Lukanov, M Ivanova, P Yankova… - Biotechnology & …, 2022 - Taylor & Francis
Polymorphisms in the genes of drug-metabolizing enzymes have the potential to contribute
to inter-individual differences in drug pharmacokinetics and toxicity. A custom next …
to inter-individual differences in drug pharmacokinetics and toxicity. A custom next …
Population pharmacokinetics and Bayesian estimation of tacrolimus exposure in Chinese liver transplant patients
B Chen, HQ Shi, XX Liu, WX Zhang… - Journal of clinical …, 2017 - Wiley Online Library
What is known and objectives Tacrolimus (TAC) is widely used as part of
immunosuppressive regimens. There is great interindividual variation on the disposition of …
immunosuppressive regimens. There is great interindividual variation on the disposition of …
[PDF][PDF] Influence of gene polymorphism on the pharamacokinetics of calcineurin inhibitors: In renal transplant patients from India
KK Vattam, KK Mukkavilli, S Moova… - Int. Res. J. Pharm …, 2013 - medicoverhospitals.in
The calcineurin inhibitors (CIs), cyclosporine (CsA) and tacrolimus (Tac), are
immunosuppressive drugs used to prevent rejection in patients with organ transplant. Both …
immunosuppressive drugs used to prevent rejection in patients with organ transplant. Both …
[HTML][HTML] Investigation of CYP 3A5 and ABCB1 gene polymorphisms in the long-term following renal transplantation: Effects on tacrolimus exposure and kidney function
NZ Stefanović, TP Cvetković… - Experimental and …, 2015 - spandidos-publications.com
The clinical use of tacrolimus (Tac) is complicated by the large inter-individual variability in
its pharmacokinetics as well as by chronic adverse effects on renal function. The main goal …
its pharmacokinetics as well as by chronic adverse effects on renal function. The main goal …
CYP3A and ABCB1 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of tacrolimus and its metabolites (MI and M-III)
Background We prospectively studied renal transplant recipients receiving tacrolimus to
determine the relationship between the CYP3A4, CYP3A5, and ABCB1 genetic …
determine the relationship between the CYP3A4, CYP3A5, and ABCB1 genetic …
[HTML][HTML] A Markov Chain Model to Evaluate the Effect of CYP3A5 and ABCB1 Polymorphisms on Adverse Events Associated with Tacrolimus in Pediatric Renal …
Abstract The SNP A6986G of the CYP3A5 gene (* 3) results in a non-functional protein due
to a splicing defect whereas the C3435T was associated with variable expression of the …
to a splicing defect whereas the C3435T was associated with variable expression of the …
Gene variations of sixth complement component affecting tacrolimus metabolism in patients with liver transplantation for hepatocellular carcinoma
JH Liao, CC Li, SH Wu, JW Fan, HT Gu… - Chinese Medical …, 2017 - mednexus.org
Background: Orthotopic liver transplantation (OLT) improves the prognosis of patients with
hepatocellular carcinoma (HCC). Moreover, the complement system is a powerful immune …
hepatocellular carcinoma (HCC). Moreover, the complement system is a powerful immune …
[HTML][HTML] Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical …
EV Alatorre-Moreno, AM Saldaña-Cruz… - Genes, 2024 - mdpi.com
Tacrolimus (TAC) is an immunosuppressant drug that prevents organ rejection after
transplantation. This drug is transported from cells via P-glycoprotein (ABCB1) and is a …
transplantation. This drug is transported from cells via P-glycoprotein (ABCB1) and is a …
[HTML][HTML] CYP3A5 and ABCB1 genotype influence tacrolimus and sirolimus pharmacokinetics in renal transplant recipients
Y Li, L Yan, Y Shi, Y Bai, J Tang, L Wang - Springerplus, 2015 - Springer
Abstract CYP3A5 and ABCB1 polymorphisms have been shown to influence tacrolimus
blood concentrations and dose requirements, but the conclusion in the current reports were …
blood concentrations and dose requirements, but the conclusion in the current reports were …