Owing to their central role in the initiation and regulation of antitumor immunity, dendritic
cells (DCs) have been widely tested for use in cancer immunotherapy. Despite several …

The discovery that dendritic cells (DC) play a key role in regulating antitumor immunity has
prompted considerable efforts in developing DC-based cancer vaccines for use in clinical …

Dendritic cells (DCs) play a central role in the initiation and regulation of primary immune
responses. DCs loaded with tumor-associated antigens induce anti-tumoral cytotoxic T cells …

Dendritic cells are specialized antigen-presenting cells that play a dual role in induction of
both innate and adaptive immunity as well as T cell tolerance. Dendritic cell based vaccines …

Dendritic cells (DCs) occupy a central position in the immune system, orchestrating a wide
repertoire of responses that span from the development of self-tolerance to the elicitation of …

Because of their unique role in linking the innate and adaptive immune systems, dendritic
cells (DCs) have been a logical focus for novel immunotherapies. However, strategies …

Dendritic cells (DCs) are versatile elements of the immune system and are best known for
their unparalleled ability to initiate and modulate adaptive immune responses. During the …

Advances in the understanding of the immunoregulatory functions of dendritic cells (DCs) in
animal models and humans have led to their exploitation as anticancer vaccines. Although …

The characterization of tumorassociated antigens recognized by human T lymphocytes in a
major histocompatibility complex (MHC) restricted fashion has opened new possibilities for …

Cancer vaccines have undergone a renaissance because of recent clinical trials showing
promising immunologic data and some clinical benefit to patients. Current trials exploiting …