Leptin (from the Greek word “lepto''meaning “thin”) is a 167-amino acid peptide hormone
encoded by the obesity (ob) gene and secreted by white adipocytes. Blood leptin …

The adipocyte-derived hormone, leptin, regulates food intake and systemic fuel metabolism;
ob/ob mice, which lack functional leptin, exhibit an obesity syndrome that is similar to morbid …

THE DISCOVERY of leptin in 1994 has provided a major new piece in the puzzle of obesity.
Leptin is a 167-amino acid peptide made exclusively in adipose tissue. Its absence …

Many studies have reported the difficulty most subjects have in maintaining weight loss.
Leptin is a cytokine-like protein made in adipose tissue and is transported into the brain by …

Leptin, a protein containing 167 amino acids, demonstrates structural similarities with
cytokine family and is mainly produced by adipocytes. The leptin receptor (OB-R) is a large …

Leptin has been shown to have a wide repertoire of peripheral effects, some of which are
mediated through the central nervous system and others that are induced through a direct …

Leptin is an adipocyte-derived hormone that is essential for normal body weight regulation.
Its main physiological role may be to coordinate the metabolic, endocrine and behavioural …

Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and
metabolic functions. In this review, we describe the role of leptin in human physiology and …

Since its discovery as an adipocyte-secreted hormone, leptin has been found to impact food
intake, energy homeostasis, and metabolism through its effects on the central nervous …

Obesity results from an abnormal accumulation of fat in the white adipose tissue. Recent
research utilizing genetic models of obesity in rodents has implicated a major role of leptin …