IKAROS is a master regulator of cell fate determination in lymphoid and other hematopoietic
cells. This transcription factor orchestrates the association of epigenetic regulators with …

Ikaros is a gene whose activity is essential for normal hematopoiesis. Ikaros acts as a master
regulator of lymphoid and myeloid development as well as a tumor suppressor. In cells …

Ikaros is the founding member of a family of zinc finger transcription factors whose function
during early hematopoietic development is required for differentiation into the three major …

The Ikaros gene encodes a zinc finger, DNA-binding protein that regulates gene
transcription and chromatin remodeling. Ikaros is a master regulator of hematopoiesis and …

The role of Ikaros in the pathogenesis of acute lymphoblastic leukemia (ALL) has been an
enigma for many years. Ikaros is a member of a family of zinc finger transcription factors that …

Ikaros is an essential transcription factor for normal lymphocyte development. Because of its
interaction with a number of closely related factors, Ikaros is required for correct regulation of …

Abstract Background The loss of Ikaros is associated with the development of B and T cell
leukemia. Data on Ikaros function, including its role as a tumor suppressor and a regulator of …

Ikaros encodes a zinc finger protein that is essential for hematopoiesis and that acts as a
tumor suppressor in leukemia. Ikaros function depends on its ability to localize to …

Regulation of oncogenic gene expression by transcription factors that function as tumor
suppressors is one of the major mechanisms that regulate leukemogenesis. Understanding …

Ikaros is a hematopoietic cell-specific zinc finger DNA binding protein that plays an
important role in lymphocyte development. Genetic disruption of Ikaros results in T-cell …