Microfluidic devices as translational research tools provide a potential alternative to animal
experiments due to their ability to mimic physiological parameters. Several approaches that …

Simple Summary Organoids, also known as self-organized 3D organ-like clusters, represent
almost a physiological system for studying cells, stem cells, tissues, and diseases, especially …

In vitro cell culture models are emerging as promising tools to understand human
development, disease progression, and provide reliable, rapid and cost-effective results for …

Abstract Three-dimensional (3D) cell culture technologies, such as organoids, are
physiologically relevant models for basic and clinical applications. Automated microfluidics …

While the potential of patient-derived organoids (PDOs) to predict patients' responses to anti-
cancer treatments has been well recognized, the lengthy time and the low efficiency in …

Individualized treatment is a promising clinical strategy for lung cancer, and drug sensitivity
testing is fundamental to this scheme. We aimed to develop an effective drug sensitivity test …

The recent advent of robust methods to grow human tissues as 3D organoids allows us to
recapitulate the 3D architecture of tumors in an in vitro setting and offers a new orthogonal …

Tumor organoids are 3D cultures of cancer cells that can be derived on an individual patient
basis with a high success rate. This creates opportunities to build large biobanks with …

There is a growing interest in developing personalized treatment strategies for each cancer
patient, especially those with non-small cell lung carcinoma (NSCLC) which annually …

Purpose: Non–small cell lung cancer (NSCLC) is the most common cause of cancer-related
deaths worldwide. There is an unmet need to develop novel clinically relevant models of …