Abstract Background and Hypothesis Dysfunction of the dopamine system is the leading
neurobiological hypothesis of schizophrenia. In this study, we tested this hypothesis in the …

Dopamine dysfunction is a mainstay of theories aimed to explain the neurobiological
correlates of schizophrenia symptoms, particularly positive symptoms such as delusions and …

Objectives Change in reward processing and motivation may mediate the relationship
between dopaminergic dysregulation and positive symptoms of schizophrenia. We sought to …

A dysregulation of the mesolimbic dopamine system in schizophrenia patients may lead to
aberrant attribution of incentive salience and contribute to the emergence of …

Background Ventral striatal hypoactivation during reward anticipation has consistently been
observed in patients with schizophrenia. In addition, that hypoactivation has been shown to …

BackgroundSmoking is highly prevalent in people diagnosed with schizophrenia, but the
reason for this co-morbidity is currently unclear. One possible explanation is that a common …

The “aberrant salience” model proposes that psychotic symptoms first emerge when chaotic
brain dopamine transmission leads to the attribution of significance to stimuli that would …

Background Delusion occupies an important position in the diagnosis and treatment of
patients with psychoses. Although Karl Jaspers' concept of the primary delusion (PD) is a …

BackgroundIt has been suggested that some psychotic symptoms reflect 'aberrant salience',
related to dysfunctional reward learning. To test this hypothesis we investigated whether …

Motivational abnormalities represent a key area of dysfunction in individuals with, or at risk
for, schizophrenia and severely limit broad domains of functioning in these populations. The …