Zinc performs diverse physiological functions, and virtually all living organisms require zinc
as an essential trace element. To identify the detailed function of zinc in fungal …

The opportunistic human pathogenic fungus Aspergillus fumigatus primarily reproduces by
forming a large number of asexual spores (conidia). Sequential activation of the central …

One of the most important features that enables Aspergillus fumigatus to grow within a
susceptible individual and to cause disease is its ability to obtain Zn2+ ions from the …

Gliotoxin is a nonribosomal peptide produced by Aspergillus fumigatus. This compound has
been proposed as an A. fumigatus virulence factor due to its cytotoxic, genotoxic, and …

Recently, we reported that zinc regulates gliotoxin biosynthesis via ZafA, which is a zinc-
responsive transcriptional activator. From an HPLC analysis of culture media of Aspergillus …

Cryptic links between apparently unrelated metabolic systems represent potential new drug
targets in fungi. Evidence of such a link between zinc and gliotoxin (GT) biosynthesis in …

Aspergillus fumigatus causes a range of human and animal diseases collectively known as
aspergillosis. A. fumigatus possesses and expresses a range of genetic determinants of …

Gliotoxin is an important virulence factor of Aspergillus fumigatus. Although GliA putatively
belongs to the major facilitator superfamily in the gliotoxin biosynthesis cluster, its roles …

Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-
modulatory molecules, including secondary metabolites (SMs), which contribute to …

The function of a number of genes in the gliotoxin biosynthetic cluster (gli) in Aspergillus
fumigatus remains unknown. Here, we demonstrate that gliK deletion from two strains of A …