Abstract Purpose of Review The functions, genetic variations and impact of apolipoprotein E
on lipoprotein metabolism in general are placed in the context of clinical practice dealing …

Summary Apolipoprotein E (apoE), a 34 kDa circulating glycoprotein of 299 amino acids,
predominantly synthesised in the liver, associates with triglyceride-rich lipoproteins to …

Major advances have been made in our understanding of the role of apolipoprotein E
(apoE) in the onset and development of atherosclerosis. Increasing evidence from both …

Apolipoprotein E (apoE) is a plasma lipoprotein which plays a basic role in the degradation
of particles rich in cholesterol and triglycerides. It is able to bind to LDL receptors, but also to …

In humans, apolipoprotein E (apoE) is a polymorphic multifunctional protein. 1 It is coded by
three alleles (2, 3, 4) of a modulator gene (level, variability, and susceptibility gene) at the …

Apolipoprotein E is a multifunctional protein that is synthesized by the liver and several
peripheral tissues and cell types, including macrophages. The protein is involved in the …

The presence of different APOE isoforms represents a well-known risk factor for
cardiovascular diseases. Besides the pleiotropic effects of APOE polymorphism on heart …

The relationship between apolipoprotein (apo) E and vascular disease has been the subject
of a considerable amount of research. However, this relationship is far from clearly defined …

The apo E locus contributes to determining the variation in plasma cholesterol levels of
healthy and diseased populations. It also influences the expression of hyperlipidemia and …

For a long time it has been suggested that apolipoprotein E 4 is a major risk factor for
coronary heart disease although indisputable proof has been lacking. However, context …