Background Chronic migraine (CM) is a debilitating neurofunctional disorder primarily
affecting females, characterized by central sensitization. Central sensitization refers to the …

Background Chronic migraine is a common and highly disabling disorder. Functional MRI
has indicated that abnormal brain region activation is linked with chronic migraine. Drugs …

Central sensitization is an important pathophysiological mechanism underlying chronic
migraine (CM). Previous studies have shown that microglial activation and subsequent …

Background According to our previous study, microglia P2X4 receptors (P2X4Rs) play a
pivotal role in the central sensitization of chronic migraine (CM). However, the molecular …

Despite the relatively high prevalence of migraine or headache, the pathophysiological
mechanisms triggering headache-associated peripheral hypersensitivities, are unknown …

Background To investigate specific brain regions and neural circuits that are responsible for
migraine chronification. Methods We established a mouse model of chronic migraine with …

The pharmacological agent nitroglycerin (NTG) elicits hyperalgesia and allodynia in mice.
This model has been used to study the neurological disorder of trigeminovascular pain or …

Background Central sensitization is considered a critical pathogenic mechanism of chronic
migraine (CM). Activation of microglia in the trigeminal nucleus caudalis (TNC) contributes to …

Background Central sensitization is one of the characters of chronic migraine (CM). Aberrant
synaptic plasticity can induce central sensitization. Oxytocin (OT), which is a hypothalamic …

Background Peripheral hypersensitivities develop in the face and hindpaws of mice with
nitroglycerin (NTG)-induced migraine. We evaluated whether diluted bee venom (DBV) …