Neuropathic pain is a prevalent and debilitating chronic disease that is characterized by
activation in glial cells in various pain‐related regions within the central nervous system …

Activation of microglia in the spinal cord following peripheral nerve injury is critical for the
development of long-lasting pain hypersensitivity. However, it remains unclear whether …

Microglial cells, the resident immune cells of the spinal cord, become activated in response
to peripheral nerve injury. Microglia activation contributes to the development of neuropathic …

In this review, we report existing preclinical evidence on how the CNS compartment as well
as sex affect microglia functions in health. We highlight that recent advances in …

Microglia are dynamic immune cells with diverse roles in maintaining homeostasis of the
central nervous system. Dysregulation of microglia has been critically implicated in the …

Increasing evidence suggests that spinal microglia regulate pathological pain in males. In
this study, we investigated the effects of several microglial and astroglial modulators on …

Chronic pain and depression are intimately linked; the combination of the two leads to
higher health care costs, lower quality of life, and worse treatment outcomes with both …

Neuronal plasticity along the pathway for sensory transmission including the spinal cord and
cortex plays an important role in chronic pain, including inflammatory and neuropathic pain …

Recent studies have suggested a sexually dimorphic role of spinal glial cells in the
maintenance of mechanical hypersensitivity in rodent models of chronic pain. We have used …

Substantial evidence has implicated microglia in neuropathic pain. After peripheral nerve
injury, microglia in the spinal cord proliferate and increase cell-surface expression of the …