Sex‐specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury
Neuropathic pain is a prevalent and debilitating chronic disease that is characterized by
activation in glial cells in various pain‐related regions within the central nervous system …
activation in glial cells in various pain‐related regions within the central nervous system …
Single-cell RNA sequencing reveals time-and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain
Activation of microglia in the spinal cord following peripheral nerve injury is critical for the
development of long-lasting pain hypersensitivity. However, it remains unclear whether …
development of long-lasting pain hypersensitivity. However, it remains unclear whether …
High-resolution transcriptome analysis reveals neuropathic pain gene-expression signatures in spinal microglia after nerve injury
Microglial cells, the resident immune cells of the spinal cord, become activated in response
to peripheral nerve injury. Microglia activation contributes to the development of neuropathic …
to peripheral nerve injury. Microglia activation contributes to the development of neuropathic …
Microglial heterogeneity in chronic pain
G Sideris-Lampretsas, M Malcangio - Brain, Behavior, and Immunity, 2021 - Elsevier
In this review, we report existing preclinical evidence on how the CNS compartment as well
as sex affect microglia functions in health. We highlight that recent advances in …
as sex affect microglia functions in health. We highlight that recent advances in …
Molecules in pain and sex: a developing story
Microglia are dynamic immune cells with diverse roles in maintaining homeostasis of the
central nervous system. Dysregulation of microglia has been critically implicated in the …
central nervous system. Dysregulation of microglia has been critically implicated in the …
Sex-dependent glial signaling in pathological pain: distinct roles of spinal microglia and astrocytes
Increasing evidence suggests that spinal microglia regulate pathological pain in males. In
this study, we investigated the effects of several microglial and astroglial modulators on …
this study, we investigated the effects of several microglial and astroglial modulators on …
Characterizing sex differences in depressive-like behavior and glial brain cell changes following peripheral nerve injury in mice
V Michailidis, NK Lidhar, C Cho… - Frontiers in Behavioral …, 2021 - frontiersin.org
Chronic pain and depression are intimately linked; the combination of the two leads to
higher health care costs, lower quality of life, and worse treatment outcomes with both …
higher health care costs, lower quality of life, and worse treatment outcomes with both …
Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse
F Zhang, KI Vadakkan, SS Kim, LJ Wu… - Molecular …, 2008 - journals.sagepub.com
Neuronal plasticity along the pathway for sensory transmission including the spinal cord and
cortex plays an important role in chronic pain, including inflammatory and neuropathic pain …
cortex plays an important role in chronic pain, including inflammatory and neuropathic pain …
Exploring the transcriptome of resident spinal microglia after collagen antibody–induced arthritis
T Fernandez-Zafra, T Gao, A Jurczak, K Sandor, Z Hore… - Pain, 2019 - journals.lww.com
Recent studies have suggested a sexually dimorphic role of spinal glial cells in the
maintenance of mechanical hypersensitivity in rodent models of chronic pain. We have used …
maintenance of mechanical hypersensitivity in rodent models of chronic pain. We have used …
Sex differences in pain: a tale of two immune cells
Substantial evidence has implicated microglia in neuropathic pain. After peripheral nerve
injury, microglia in the spinal cord proliferate and increase cell-surface expression of the …
injury, microglia in the spinal cord proliferate and increase cell-surface expression of the …