Does supplementation of oocytes with additional mtDNA influence developmental outcome?
Introducing extra mitochondrial DNA (mtDNA) into oocytes at fertilization can rescue poor
quality oocytes. However, supplementation alters DNA methylation and gene expression …
quality oocytes. However, supplementation alters DNA methylation and gene expression …
Mitochondrial supplementation of Sus scrofa metaphase II oocytes alters DNA methylation and gene expression profiles of blastocysts
Abstract Background Mitochondrial DNA (mtDNA) copy number in oocytes correlates with
oocyte quality and fertilisation outcome. The introduction of additional copies of mtDNA …
oocyte quality and fertilisation outcome. The introduction of additional copies of mtDNA …
Mitochondrial DNA Supplementation of Oocytes Has Downstream Effects on the Transcriptional Profiles of Sus scrofa Adult Tissues with High mtDNA Copy Number
T Okada, A Penn, JC St. John - International Journal of Molecular …, 2023 - mdpi.com
Oocytes can be supplemented with extra copies of mitochondrial DNA (mtDNA) to enhance
developmental outcome. Pigs generated through supplementation with mtDNA derived from …
developmental outcome. Pigs generated through supplementation with mtDNA derived from …
Transmission of dysfunctional mitochondrial DNA and its implications for mammalian reproduction
K Srirattana, JC St. John - Cellular and Molecular Basis of Mitochondrial …, 2019 - Springer
Mitochondrial DNA (mtDNA) encodes proteins for the electron transport chain which
produces the vast majority of cellular energy. MtDNA has its own replication and …
produces the vast majority of cellular energy. MtDNA has its own replication and …
The effects of mitochondrial DNA supplementation at the time of fertilization on the gene expression profiles of porcine preimplantation embryos
TS Tsai, JC St. John - Molecular Reproduction and …, 2018 - Wiley Online Library
Mitochondrial DNA (mtDNA) deficient metaphase II porcine oocytes are less likely to fertilize
and more likely to arrest during preimplantation development. However, they can be …
and more likely to arrest during preimplantation development. However, they can be …
Use of bisection to reduce mitochondrial DNA in the bovine oocyte
Interspecies somatic cell nuclear transfer (iSCNT) may be used to rescue endangered
species, but two distinct populations of mitochondrial DNA (mtDNA) exist within the …
species, but two distinct populations of mitochondrial DNA (mtDNA) exist within the …
Mitochondrial DNA Deficiency and Supplementation in Sus scrofa Oocytes Influence Transcriptome Profiles in Oocytes and Blastocysts
T Okada, S McIlfatrick, JC St. John - International journal of molecular …, 2023 - mdpi.com
Mitochondrial DNA (mtDNA) deficiency correlates with poor oocyte quality and fertilisation
failure. However, the supplementation of mtDNA deficient oocytes with extra copies of …
failure. However, the supplementation of mtDNA deficient oocytes with extra copies of …
The molecular characterisation of mitochondrial DNA deficient oocytes using a pig model
STUDY QUESTION What are the molecular differences between mitochondrial DNA
(mtDNA)-deficient and mtDNA-normal oocytes and how does mitochondrial …
(mtDNA)-deficient and mtDNA-normal oocytes and how does mitochondrial …
Mitochondrial DNA content decreases during in vitro human embryo development: insights into mitochondrial DNA variation in preimplantation embryos donated for …
M Pérez-Sánchez, A Díez-Juan, D Beltrán, A Mifsud… - F&S Science, 2020 - Elsevier
Objective To assess the mitochondrial DNA (mtDNA) load and variation in human oocytes
and during preimplantation embryo development using specimens donated for research …
and during preimplantation embryo development using specimens donated for research …
Mitochondrial DNA content is associated with ploidy status, maternal age, and oocyte maturation methods in mouse blastocysts
X Tao, JN Landis, RL Krisher, FE Duncan… - Journal of Assisted …, 2017 - Springer
Purpose It was reported that mitochondrial DNA (mtDNA) was significantly increased in
aneuploid human embryos compared to euploid embryos and was also associated with …
aneuploid human embryos compared to euploid embryos and was also associated with …